Sequential monitoring of urine-soluble interleukin 2 receptor and interleukin 6 predicts acute rejection of human renal allografts before clinical or laboratory signs of renal dysfunction

Federica Casiraghi, Piero Ruggenenti, Marina Noris, Giuseppe Locatelli, Norberto Perico, Annalisa Perna, Giuseppe Remuzzi

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background. The significance of noninvasive techniques to the early diagnosis of acute rejection in kidney transplants remains elusive. In this study, we examined whether an early posttransplant increase in serum- and urine-soluble interleukin (IL) 2 receptor (sIL-2R) and IL-6 levels predicted acute rejection. Methods. Sequential determinations of serum and urine sIL- 2R and IL-6 were performed in the first 30 postoperative days in 40 renal transplant patients. Changes during the posttransplant period observed in 26 patients who had one or more episodes of acute rejection (group A) were compared with those recorded in 14 patients who did not experience acute rejection of their graft (group B). Results. Serum sIL-2R was higher than normal in patients of groups A and B without statistical differences between the two groups. In the first 3 days after transplantation, urinary sIL-2R was higher than normal in group A but not in group B. Urinary sIL-2R at days 2 and 3 was significantly higher (P

Original languageEnglish
Pages (from-to)1508-1514
Number of pages7
JournalTransplantation
Volume63
Issue number10
DOIs
Publication statusPublished - May 27 1997

Fingerprint

Interleukin-2 Receptors
Allografts
Interleukin-6
Urine
Kidney
Serum
Transplants
Graft Rejection
Early Diagnosis
Transplantation

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

@article{8d8311f8b7714ce788a8b37489f912d8,
title = "Sequential monitoring of urine-soluble interleukin 2 receptor and interleukin 6 predicts acute rejection of human renal allografts before clinical or laboratory signs of renal dysfunction",
abstract = "Background. The significance of noninvasive techniques to the early diagnosis of acute rejection in kidney transplants remains elusive. In this study, we examined whether an early posttransplant increase in serum- and urine-soluble interleukin (IL) 2 receptor (sIL-2R) and IL-6 levels predicted acute rejection. Methods. Sequential determinations of serum and urine sIL- 2R and IL-6 were performed in the first 30 postoperative days in 40 renal transplant patients. Changes during the posttransplant period observed in 26 patients who had one or more episodes of acute rejection (group A) were compared with those recorded in 14 patients who did not experience acute rejection of their graft (group B). Results. Serum sIL-2R was higher than normal in patients of groups A and B without statistical differences between the two groups. In the first 3 days after transplantation, urinary sIL-2R was higher than normal in group A but not in group B. Urinary sIL-2R at days 2 and 3 was significantly higher (P",
author = "Federica Casiraghi and Piero Ruggenenti and Marina Noris and Giuseppe Locatelli and Norberto Perico and Annalisa Perna and Giuseppe Remuzzi",
year = "1997",
month = "5",
day = "27",
doi = "10.1097/00007890-199705270-00023",
language = "English",
volume = "63",
pages = "1508--1514",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - Sequential monitoring of urine-soluble interleukin 2 receptor and interleukin 6 predicts acute rejection of human renal allografts before clinical or laboratory signs of renal dysfunction

AU - Casiraghi, Federica

AU - Ruggenenti, Piero

AU - Noris, Marina

AU - Locatelli, Giuseppe

AU - Perico, Norberto

AU - Perna, Annalisa

AU - Remuzzi, Giuseppe

PY - 1997/5/27

Y1 - 1997/5/27

N2 - Background. The significance of noninvasive techniques to the early diagnosis of acute rejection in kidney transplants remains elusive. In this study, we examined whether an early posttransplant increase in serum- and urine-soluble interleukin (IL) 2 receptor (sIL-2R) and IL-6 levels predicted acute rejection. Methods. Sequential determinations of serum and urine sIL- 2R and IL-6 were performed in the first 30 postoperative days in 40 renal transplant patients. Changes during the posttransplant period observed in 26 patients who had one or more episodes of acute rejection (group A) were compared with those recorded in 14 patients who did not experience acute rejection of their graft (group B). Results. Serum sIL-2R was higher than normal in patients of groups A and B without statistical differences between the two groups. In the first 3 days after transplantation, urinary sIL-2R was higher than normal in group A but not in group B. Urinary sIL-2R at days 2 and 3 was significantly higher (P

AB - Background. The significance of noninvasive techniques to the early diagnosis of acute rejection in kidney transplants remains elusive. In this study, we examined whether an early posttransplant increase in serum- and urine-soluble interleukin (IL) 2 receptor (sIL-2R) and IL-6 levels predicted acute rejection. Methods. Sequential determinations of serum and urine sIL- 2R and IL-6 were performed in the first 30 postoperative days in 40 renal transplant patients. Changes during the posttransplant period observed in 26 patients who had one or more episodes of acute rejection (group A) were compared with those recorded in 14 patients who did not experience acute rejection of their graft (group B). Results. Serum sIL-2R was higher than normal in patients of groups A and B without statistical differences between the two groups. In the first 3 days after transplantation, urinary sIL-2R was higher than normal in group A but not in group B. Urinary sIL-2R at days 2 and 3 was significantly higher (P

UR - http://www.scopus.com/inward/record.url?scp=0030949082&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030949082&partnerID=8YFLogxK

U2 - 10.1097/00007890-199705270-00023

DO - 10.1097/00007890-199705270-00023

M3 - Article

C2 - 9175818

AN - SCOPUS:0030949082

VL - 63

SP - 1508

EP - 1514

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 10

ER -