Sequential monitoring of urine-soluble interleukin 2 receptor and interleukin 6 predicts acute rejection of human renal allografts before clinical or laboratory signs of renal dysfunction

Federica Casiraghi, Piero Ruggenenti, Marina Noris, Giuseppe Locatelli, Norberto Perico, Annalisa Perna, Giuseppe Remuzzi

Research output: Contribution to journalArticlepeer-review

Abstract

Background. The significance of noninvasive techniques to the early diagnosis of acute rejection in kidney transplants remains elusive. In this study, we examined whether an early posttransplant increase in serum- and urine-soluble interleukin (IL) 2 receptor (sIL-2R) and IL-6 levels predicted acute rejection. Methods. Sequential determinations of serum and urine sIL- 2R and IL-6 were performed in the first 30 postoperative days in 40 renal transplant patients. Changes during the posttransplant period observed in 26 patients who had one or more episodes of acute rejection (group A) were compared with those recorded in 14 patients who did not experience acute rejection of their graft (group B). Results. Serum sIL-2R was higher than normal in patients of groups A and B without statistical differences between the two groups. In the first 3 days after transplantation, urinary sIL-2R was higher than normal in group A but not in group B. Urinary sIL-2R at days 2 and 3 was significantly higher (P

Original languageEnglish
Pages (from-to)1508-1514
Number of pages7
JournalTransplantation
Volume63
Issue number10
DOIs
Publication statusPublished - May 27 1997

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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