Sequential transmission and long-term persistence of an HIV strain partially resistant to protease inhibitors

Ennio Polilli, Francesco Di Masi, Federica Sozio, Elena Mazzotta, Luciana Alterio, Luana Cosentino, Luigi Clerico, Carlo Federico Perno, Giustino Parruti

Research output: Contribution to journalArticle

Abstract

Transmission of drug-resistant HIV-1 variants has been increasingly documented. The most commonly observed resistance-associated mutations are thymidine analogue mutations as well as non-nucleoside reverse transcriptase inhibitor mutations. We report on a case of secondary transmission of a protease inhibitor (PI) primary mutation from an infected untreated subject to his sexual partner. Sequences isolated from the 2 patients showed a high level of identity (>99%), both carrying the major IAS PI mutation M46I. The latter mutation persisted in the bloodstream of the female partner 1 year after its first detection.

Original languageEnglish
Pages (from-to)205-208
Number of pages4
JournalNew Microbiologica
Volume32
Issue number2
Publication statusPublished - Apr 2009

Keywords

  • HIV
  • Resistance testing
  • Sequential transmission of resistance

ASJC Scopus subject areas

  • Microbiology (medical)

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    Polilli, E., Masi, F. D., Sozio, F., Mazzotta, E., Alterio, L., Cosentino, L., Clerico, L., Perno, C. F., & Parruti, G. (2009). Sequential transmission and long-term persistence of an HIV strain partially resistant to protease inhibitors. New Microbiologica, 32(2), 205-208.