Of 93 patients with pretreated, BRAFV600 mutation-positive advanced melanoma who received vemurafenib or dabrafenib before (n = 45) or after (n = 48) treatment with ipilimumab 3 mg/kg, median overall survival (mOS) from first treatment was 9.9 and 14.5 months, respectively. Among patients treated with a BRAF inhibitor first, mOS from the end of BRAF inhibition was 1.2 months for those who did not complete ipilimumab treatment as per protocol, compared with 12.7 months for those who did (p <.001). Prospective, randomized studies are required to determine the optimal sequencing of ipilimumab and BRAF inhibitors in patients with BRAF-mutated metastatic melanoma.

Original languageEnglish
Pages (from-to)144-149
Number of pages6
JournalCancer Investigation
Issue number4
Publication statusPublished - 2014


  • Cutaneous melanoma
  • Molecular biology
  • Treatment
  • Tumor immunology

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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