Sera from AIDS patients inhibit the responsiveness of normal lymphocytes in allogeneic and autologous mixed lymphocyte cultures.

F. Puppo, R. Stagnaro, R. Ruzzenenti, F. Indiveri

Research output: Contribution to journalArticle

Abstract

We analyzed the effects of 10 sera from patients with AIDS on the responsiveness of normal lymphocytes in allogeneic and autologous mixed lymphocyte cultures (MLR and AMLR). Results show that all AIDS sera significantly inhibit lymphocyte responsiveness in either MLR or AMLR of non-T/T and T/T type. Experiments performed to asses the effects of heat inactivated sera or sera fractions (obtained by ultracentrifugation on membranes with predetermined pore diameters) on either stimulator or responder cells, showed that the suppressive effects are attributable to heat stable factors with a wide range of molecular weights that act mainly on responder T cells. Present data suggest that circulating factors with inhibitory effects on MLR and AMLR responses can be found in AIDS sera. These factors might contribute to the immunosuppression of AIDS patients.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalAllergologia et Immunopathologia
Volume19
Issue number2
Publication statusPublished - Mar 1991

ASJC Scopus subject areas

  • Immunology and Allergy

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