Serial determinations of leukocyte aggregation in patients with ischemic stroke

A. Galante, A. Pietroiusti, A. Magrini, R. Floris, G. Simonetti, M. Silvestrini, P. Stanzione, G. Bernardi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The pattern of leukocyte aggregation and its possible relationship with the clinical outcome were evaluated in 35 untreated patients with acute cerebrovascular disease during each of the first three days of hospitalization. Although statistically significant differences were found when comparing patients and age and sex matched controls during any of the 3 days, a large overlapping of values was noted in each comparison. The overlapping was strongly reduced when the average 3-day value was compared. Similarly, when comparing subgroups of patients classified on the basis of their clinical status, the overlap of values observed during any of the 3 days dropped from 70% to 30% when considering the average 3-day levels of leukocyte aggregation. Furthermore, the level of correlation between leukocyte aggregation and size of cerebral infarction was better when considering the average 3-day value (p = 005) than the best single-day correlation (p = 01). These data suggest that the association between acute cerebrovascular ischemia and leukocyte rheology is better discovered when repeated evaluation of the latter are performed.

Original languageEnglish
Pages (from-to)69-76
Number of pages8
JournalInternational Journal of Neuroscience
Volume73
Issue number1-2
DOIs
Publication statusPublished - 1993

Fingerprint

Leukocytes
Stroke
Cerebrovascular Disorders
Rheology
Cerebral Infarction
Acute Disease
Hospitalization
Ischemia

Keywords

  • Infarct size
  • Leukocyte aggregation
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Galante, A., Pietroiusti, A., Magrini, A., Floris, R., Simonetti, G., Silvestrini, M., ... Bernardi, G. (1993). Serial determinations of leukocyte aggregation in patients with ischemic stroke. International Journal of Neuroscience, 73(1-2), 69-76. https://doi.org/10.3109/00207459308987212

Serial determinations of leukocyte aggregation in patients with ischemic stroke. / Galante, A.; Pietroiusti, A.; Magrini, A.; Floris, R.; Simonetti, G.; Silvestrini, M.; Stanzione, P.; Bernardi, G.

In: International Journal of Neuroscience, Vol. 73, No. 1-2, 1993, p. 69-76.

Research output: Contribution to journalArticle

Galante, A, Pietroiusti, A, Magrini, A, Floris, R, Simonetti, G, Silvestrini, M, Stanzione, P & Bernardi, G 1993, 'Serial determinations of leukocyte aggregation in patients with ischemic stroke', International Journal of Neuroscience, vol. 73, no. 1-2, pp. 69-76. https://doi.org/10.3109/00207459308987212
Galante A, Pietroiusti A, Magrini A, Floris R, Simonetti G, Silvestrini M et al. Serial determinations of leukocyte aggregation in patients with ischemic stroke. International Journal of Neuroscience. 1993;73(1-2):69-76. https://doi.org/10.3109/00207459308987212
Galante, A. ; Pietroiusti, A. ; Magrini, A. ; Floris, R. ; Simonetti, G. ; Silvestrini, M. ; Stanzione, P. ; Bernardi, G. / Serial determinations of leukocyte aggregation in patients with ischemic stroke. In: International Journal of Neuroscience. 1993 ; Vol. 73, No. 1-2. pp. 69-76.
@article{8efbb9fbc3e543249c1f1ad10fc88fb6,
title = "Serial determinations of leukocyte aggregation in patients with ischemic stroke",
abstract = "The pattern of leukocyte aggregation and its possible relationship with the clinical outcome were evaluated in 35 untreated patients with acute cerebrovascular disease during each of the first three days of hospitalization. Although statistically significant differences were found when comparing patients and age and sex matched controls during any of the 3 days, a large overlapping of values was noted in each comparison. The overlapping was strongly reduced when the average 3-day value was compared. Similarly, when comparing subgroups of patients classified on the basis of their clinical status, the overlap of values observed during any of the 3 days dropped from 70{\%} to 30{\%} when considering the average 3-day levels of leukocyte aggregation. Furthermore, the level of correlation between leukocyte aggregation and size of cerebral infarction was better when considering the average 3-day value (p = 005) than the best single-day correlation (p = 01). These data suggest that the association between acute cerebrovascular ischemia and leukocyte rheology is better discovered when repeated evaluation of the latter are performed.",
keywords = "Infarct size, Leukocyte aggregation, Stroke",
author = "A. Galante and A. Pietroiusti and A. Magrini and R. Floris and G. Simonetti and M. Silvestrini and P. Stanzione and G. Bernardi",
year = "1993",
doi = "10.3109/00207459308987212",
language = "English",
volume = "73",
pages = "69--76",
journal = "International Journal of Neuroscience",
issn = "0020-7454",
publisher = "Informa Healthcare",
number = "1-2",

}

TY - JOUR

T1 - Serial determinations of leukocyte aggregation in patients with ischemic stroke

AU - Galante, A.

AU - Pietroiusti, A.

AU - Magrini, A.

AU - Floris, R.

AU - Simonetti, G.

AU - Silvestrini, M.

AU - Stanzione, P.

AU - Bernardi, G.

PY - 1993

Y1 - 1993

N2 - The pattern of leukocyte aggregation and its possible relationship with the clinical outcome were evaluated in 35 untreated patients with acute cerebrovascular disease during each of the first three days of hospitalization. Although statistically significant differences were found when comparing patients and age and sex matched controls during any of the 3 days, a large overlapping of values was noted in each comparison. The overlapping was strongly reduced when the average 3-day value was compared. Similarly, when comparing subgroups of patients classified on the basis of their clinical status, the overlap of values observed during any of the 3 days dropped from 70% to 30% when considering the average 3-day levels of leukocyte aggregation. Furthermore, the level of correlation between leukocyte aggregation and size of cerebral infarction was better when considering the average 3-day value (p = 005) than the best single-day correlation (p = 01). These data suggest that the association between acute cerebrovascular ischemia and leukocyte rheology is better discovered when repeated evaluation of the latter are performed.

AB - The pattern of leukocyte aggregation and its possible relationship with the clinical outcome were evaluated in 35 untreated patients with acute cerebrovascular disease during each of the first three days of hospitalization. Although statistically significant differences were found when comparing patients and age and sex matched controls during any of the 3 days, a large overlapping of values was noted in each comparison. The overlapping was strongly reduced when the average 3-day value was compared. Similarly, when comparing subgroups of patients classified on the basis of their clinical status, the overlap of values observed during any of the 3 days dropped from 70% to 30% when considering the average 3-day levels of leukocyte aggregation. Furthermore, the level of correlation between leukocyte aggregation and size of cerebral infarction was better when considering the average 3-day value (p = 005) than the best single-day correlation (p = 01). These data suggest that the association between acute cerebrovascular ischemia and leukocyte rheology is better discovered when repeated evaluation of the latter are performed.

KW - Infarct size

KW - Leukocyte aggregation

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=0027688951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027688951&partnerID=8YFLogxK

U2 - 10.3109/00207459308987212

DO - 10.3109/00207459308987212

M3 - Article

C2 - 8132420

AN - SCOPUS:0027688951

VL - 73

SP - 69

EP - 76

JO - International Journal of Neuroscience

JF - International Journal of Neuroscience

SN - 0020-7454

IS - 1-2

ER -