Abstract
Flash electroretinograms (ERG) were recorded to characterise the pathophysiological features of 11 adults receiving VGB with other antiepilepsy drugs (AED), six of whom discontinued VGB and nine children who received VGB alone [M.A. Johnson, G.L. Krauss, N.R. Miller, M. Medura, S.R. Paul. Visual function loss from vigabatrin: effect of stopping the drug. Neurology 55(1) (2000) 40-45.] or with other AEDs [H.S. Graniewski-Wijnands, T.K. van der. Electro-ophthalmological recovery after withdrawal from vigabatrin. Doc Ophthalmol 104(2) (2002) 189-194.], five of whom discontinued VGB. Abnormal b-waves were found in 16%, FLK in 50% and OPs in 76%. Of the nine patients continuing VGB (four children and five adults), one child had attenuated OPs and two unchanged ERGs; two of the adults had unchanged ERGs, and two had b-wave and/or FLK and/or OP changes. The ERGs of 4/5 children discontinuing VGB greatly improved; the ERGs of the fifth remained unchanged; 4/6 adults discontinuing VGB showed mild-moderate FLK and OP improvements, and two remained unchanged. Serial electrophysiological recordings suggested that abnormal ERGs variably reversed upon VGB discontinuation. The most remarkable improvement was observed in children who discontinued the drug because of dim-blue attenuation. The patients continuing VGB treatment had stable or worsening abnormal findings; however, two adults on long-term treatment had normal ERGs, and one child with a visual field nasal defect had stable abnormal dim-blue findings.
| Original language | English |
|---|---|
| Pages (from-to) | 41-44 |
| Number of pages | 4 |
| Journal | International Congress Series |
| Volume | 1278 |
| DOIs | |
| Publication status | Published - Mar 2005 |
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Keywords
- Electroretinogram
- Retina
- Toxicity
- Vigabatrin
ASJC Scopus subject areas
- Medicine(all)
Cite this
Serial electrophysiological studies of the visual pathway in patients treated with vigabatrin. / Scaioli, V.; Franceschetti, S.; Binelli, S.; Casazza, M.; Villani, F.; Granata, T.; Balestrini, M. R.; Curzi, S.; Agazzi, P.; Avanzini, G.
In: International Congress Series, Vol. 1278, 03.2005, p. 41-44.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serial electrophysiological studies of the visual pathway in patients treated with vigabatrin
AU - Scaioli, V.
AU - Franceschetti, S.
AU - Binelli, S.
AU - Casazza, M.
AU - Villani, F.
AU - Granata, T.
AU - Balestrini, M. R.
AU - Curzi, S.
AU - Agazzi, P.
AU - Avanzini, G.
PY - 2005/3
Y1 - 2005/3
N2 - Flash electroretinograms (ERG) were recorded to characterise the pathophysiological features of 11 adults receiving VGB with other antiepilepsy drugs (AED), six of whom discontinued VGB and nine children who received VGB alone [M.A. Johnson, G.L. Krauss, N.R. Miller, M. Medura, S.R. Paul. Visual function loss from vigabatrin: effect of stopping the drug. Neurology 55(1) (2000) 40-45.] or with other AEDs [H.S. Graniewski-Wijnands, T.K. van der. Electro-ophthalmological recovery after withdrawal from vigabatrin. Doc Ophthalmol 104(2) (2002) 189-194.], five of whom discontinued VGB. Abnormal b-waves were found in 16%, FLK in 50% and OPs in 76%. Of the nine patients continuing VGB (four children and five adults), one child had attenuated OPs and two unchanged ERGs; two of the adults had unchanged ERGs, and two had b-wave and/or FLK and/or OP changes. The ERGs of 4/5 children discontinuing VGB greatly improved; the ERGs of the fifth remained unchanged; 4/6 adults discontinuing VGB showed mild-moderate FLK and OP improvements, and two remained unchanged. Serial electrophysiological recordings suggested that abnormal ERGs variably reversed upon VGB discontinuation. The most remarkable improvement was observed in children who discontinued the drug because of dim-blue attenuation. The patients continuing VGB treatment had stable or worsening abnormal findings; however, two adults on long-term treatment had normal ERGs, and one child with a visual field nasal defect had stable abnormal dim-blue findings.
AB - Flash electroretinograms (ERG) were recorded to characterise the pathophysiological features of 11 adults receiving VGB with other antiepilepsy drugs (AED), six of whom discontinued VGB and nine children who received VGB alone [M.A. Johnson, G.L. Krauss, N.R. Miller, M. Medura, S.R. Paul. Visual function loss from vigabatrin: effect of stopping the drug. Neurology 55(1) (2000) 40-45.] or with other AEDs [H.S. Graniewski-Wijnands, T.K. van der. Electro-ophthalmological recovery after withdrawal from vigabatrin. Doc Ophthalmol 104(2) (2002) 189-194.], five of whom discontinued VGB. Abnormal b-waves were found in 16%, FLK in 50% and OPs in 76%. Of the nine patients continuing VGB (four children and five adults), one child had attenuated OPs and two unchanged ERGs; two of the adults had unchanged ERGs, and two had b-wave and/or FLK and/or OP changes. The ERGs of 4/5 children discontinuing VGB greatly improved; the ERGs of the fifth remained unchanged; 4/6 adults discontinuing VGB showed mild-moderate FLK and OP improvements, and two remained unchanged. Serial electrophysiological recordings suggested that abnormal ERGs variably reversed upon VGB discontinuation. The most remarkable improvement was observed in children who discontinued the drug because of dim-blue attenuation. The patients continuing VGB treatment had stable or worsening abnormal findings; however, two adults on long-term treatment had normal ERGs, and one child with a visual field nasal defect had stable abnormal dim-blue findings.
KW - Electroretinogram
KW - Retina
KW - Toxicity
KW - Vigabatrin
UR - http://www.scopus.com/inward/record.url?scp=33646441945&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646441945&partnerID=8YFLogxK
U2 - 10.1016/j.ics.2004.11.115
DO - 10.1016/j.ics.2004.11.115
M3 - Article
VL - 1278
SP - 41
EP - 44
JO - International Congress Series
JF - International Congress Series
SN - 0531-5131
ER -