Abstract
We compared the sensitivity of single and triple dose Gd-DTPA magnetic resonance imaging (MRI) in detecting enhancing lesions in the spinal cord (SC) from 15 patients with multiple sclerosis (MS). The patients were examined monthly on four occasions. We detected two enhancing lesions in two of 15 (13%) patients when a single dose of Gd-DTPA was used. No additional lesions were detected when a triple dose of Gd-DTPA was used. These results 1) confirm that enhanced spinal cord imaging does not significantly increase the detection of active lesions in MS, 2) they do not support the general application of triple dose Gd-DTPA when examining the SC but 3) suggest that further studies taking into account SC symptoms are necessary. (C) 2000 Elsevier Science Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 1183-1186 |
| Number of pages | 4 |
| Journal | Magnetic Resonance Imaging |
| Volume | 18 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2000 |
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Keywords
- Comparative studies
- Contrast enhancement
- Gadolinium-DTPA
- Multiple sclerosis
- Spinal cord
- Triple dose
ASJC Scopus subject areas
- Biophysics
- Clinical Biochemistry
- Structural Biology
- Radiology Nuclear Medicine and imaging
- Condensed Matter Physics
Cite this
Serial gadolinium-DTPA of spinal cord MRI in multiple sclerosis : Triple vs. single dose. / Yousry, Indra; Filippi, Massimo; Walther, Ernst; Gasperini, Claudio; Capra, Ruggero; Yousry, Tarek A.
In: Magnetic Resonance Imaging, Vol. 18, No. 9, 2000, p. 1183-1186.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serial gadolinium-DTPA of spinal cord MRI in multiple sclerosis
T2 - Triple vs. single dose
AU - Yousry, Indra
AU - Filippi, Massimo
AU - Walther, Ernst
AU - Gasperini, Claudio
AU - Capra, Ruggero
AU - Yousry, Tarek A.
PY - 2000
Y1 - 2000
N2 - We compared the sensitivity of single and triple dose Gd-DTPA magnetic resonance imaging (MRI) in detecting enhancing lesions in the spinal cord (SC) from 15 patients with multiple sclerosis (MS). The patients were examined monthly on four occasions. We detected two enhancing lesions in two of 15 (13%) patients when a single dose of Gd-DTPA was used. No additional lesions were detected when a triple dose of Gd-DTPA was used. These results 1) confirm that enhanced spinal cord imaging does not significantly increase the detection of active lesions in MS, 2) they do not support the general application of triple dose Gd-DTPA when examining the SC but 3) suggest that further studies taking into account SC symptoms are necessary. (C) 2000 Elsevier Science Inc.
AB - We compared the sensitivity of single and triple dose Gd-DTPA magnetic resonance imaging (MRI) in detecting enhancing lesions in the spinal cord (SC) from 15 patients with multiple sclerosis (MS). The patients were examined monthly on four occasions. We detected two enhancing lesions in two of 15 (13%) patients when a single dose of Gd-DTPA was used. No additional lesions were detected when a triple dose of Gd-DTPA was used. These results 1) confirm that enhanced spinal cord imaging does not significantly increase the detection of active lesions in MS, 2) they do not support the general application of triple dose Gd-DTPA when examining the SC but 3) suggest that further studies taking into account SC symptoms are necessary. (C) 2000 Elsevier Science Inc.
KW - Comparative studies
KW - Contrast enhancement
KW - Gadolinium-DTPA
KW - Multiple sclerosis
KW - Spinal cord
KW - Triple dose
UR - http://www.scopus.com/inward/record.url?scp=0034535654&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034535654&partnerID=8YFLogxK
U2 - 10.1016/S0730-725X(00)00191-0
DO - 10.1016/S0730-725X(00)00191-0
M3 - Article
VL - 18
SP - 1183
EP - 1186
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
SN - 0730-725X
IS - 9
ER -