Serial gadolinium-DTPA of spinal cord MRI in multiple sclerosis: Triple vs. single dose

Indra Yousry, Massimo Filippi, Ernst Walther, Claudio Gasperini, Ruggero Capra, Tarek A. Yousry

Research output: Contribution to journalArticlepeer-review


We compared the sensitivity of single and triple dose Gd-DTPA magnetic resonance imaging (MRI) in detecting enhancing lesions in the spinal cord (SC) from 15 patients with multiple sclerosis (MS). The patients were examined monthly on four occasions. We detected two enhancing lesions in two of 15 (13%) patients when a single dose of Gd-DTPA was used. No additional lesions were detected when a triple dose of Gd-DTPA was used. These results 1) confirm that enhanced spinal cord imaging does not significantly increase the detection of active lesions in MS, 2) they do not support the general application of triple dose Gd-DTPA when examining the SC but 3) suggest that further studies taking into account SC symptoms are necessary. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)1183-1186
Number of pages4
JournalMagnetic Resonance Imaging
Issue number9
Publication statusPublished - 2000


  • Comparative studies
  • Contrast enhancement
  • Gadolinium-DTPA
  • Multiple sclerosis
  • Spinal cord
  • Triple dose

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics


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