Serial gadolinium-DTPA of spinal cord MRI in multiple sclerosis: Triple vs. single dose

Indra Yousry; Massimo Filippi; Ernst Walther; Claudio Gasperini; Ruggero Capra; Tarek A. Yousry

doi:10.1016/S0730-725X(00)00191-0

Serial gadolinium-DTPA of spinal cord MRI in multiple sclerosis: Triple vs. single dose

Indra Yousry, Massimo Filippi, Ernst Walther, Claudio Gasperini, Ruggero Capra, Tarek A. Yousry

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

We compared the sensitivity of single and triple dose Gd-DTPA magnetic resonance imaging (MRI) in detecting enhancing lesions in the spinal cord (SC) from 15 patients with multiple sclerosis (MS). The patients were examined monthly on four occasions. We detected two enhancing lesions in two of 15 (13%) patients when a single dose of Gd-DTPA was used. No additional lesions were detected when a triple dose of Gd-DTPA was used. These results 1) confirm that enhanced spinal cord imaging does not significantly increase the detection of active lesions in MS, 2) they do not support the general application of triple dose Gd-DTPA when examining the SC but 3) suggest that further studies taking into account SC symptoms are necessary. (C) 2000 Elsevier Science Inc.

Original language	English
Pages (from-to)	1183-1186
Number of pages	4
Journal	Magnetic Resonance Imaging
Volume	18
Issue number	9
DOIs	https://doi.org/10.1016/S0730-725X(00)00191-0
Publication status	Published - 2000

Keywords

Comparative studies
Contrast enhancement
Gadolinium-DTPA
Multiple sclerosis
Spinal cord
Triple dose

ASJC Scopus subject areas

Biophysics
Clinical Biochemistry
Structural Biology
Radiology Nuclear Medicine and imaging
Condensed Matter Physics

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title = "Serial gadolinium-DTPA of spinal cord MRI in multiple sclerosis: Triple vs. single dose",

abstract = "We compared the sensitivity of single and triple dose Gd-DTPA magnetic resonance imaging (MRI) in detecting enhancing lesions in the spinal cord (SC) from 15 patients with multiple sclerosis (MS). The patients were examined monthly on four occasions. We detected two enhancing lesions in two of 15 (13%) patients when a single dose of Gd-DTPA was used. No additional lesions were detected when a triple dose of Gd-DTPA was used. These results 1) confirm that enhanced spinal cord imaging does not significantly increase the detection of active lesions in MS, 2) they do not support the general application of triple dose Gd-DTPA when examining the SC but 3) suggest that further studies taking into account SC symptoms are necessary. (C) 2000 Elsevier Science Inc.",

keywords = "Comparative studies, Contrast enhancement, Gadolinium-DTPA, Multiple sclerosis, Spinal cord, Triple dose",

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T1 - Serial gadolinium-DTPA of spinal cord MRI in multiple sclerosis

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AU - Yousry, Indra

AU - Filippi, Massimo

AU - Walther, Ernst

AU - Gasperini, Claudio

AU - Capra, Ruggero

AU - Yousry, Tarek A.

PY - 2000

Y1 - 2000

N2 - We compared the sensitivity of single and triple dose Gd-DTPA magnetic resonance imaging (MRI) in detecting enhancing lesions in the spinal cord (SC) from 15 patients with multiple sclerosis (MS). The patients were examined monthly on four occasions. We detected two enhancing lesions in two of 15 (13%) patients when a single dose of Gd-DTPA was used. No additional lesions were detected when a triple dose of Gd-DTPA was used. These results 1) confirm that enhanced spinal cord imaging does not significantly increase the detection of active lesions in MS, 2) they do not support the general application of triple dose Gd-DTPA when examining the SC but 3) suggest that further studies taking into account SC symptoms are necessary. (C) 2000 Elsevier Science Inc.

AB - We compared the sensitivity of single and triple dose Gd-DTPA magnetic resonance imaging (MRI) in detecting enhancing lesions in the spinal cord (SC) from 15 patients with multiple sclerosis (MS). The patients were examined monthly on four occasions. We detected two enhancing lesions in two of 15 (13%) patients when a single dose of Gd-DTPA was used. No additional lesions were detected when a triple dose of Gd-DTPA was used. These results 1) confirm that enhanced spinal cord imaging does not significantly increase the detection of active lesions in MS, 2) they do not support the general application of triple dose Gd-DTPA when examining the SC but 3) suggest that further studies taking into account SC symptoms are necessary. (C) 2000 Elsevier Science Inc.

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