Serial gadolinium-enhanced MRI in patients with multiple sclerosis of varying levels of disability

G. Mastronardo, M. A. Rocca, P. Rossi, B. Colombo, N. Canal, G. Comi, M. Filippi

Research output: Contribution to journalArticlepeer-review

Abstract

This study was performed to compare the rates of enhancement and changes in lesion burden in patients with multiple sclerosis (MS) and varying levels of disability. Monthly enhanced magnetic resonance imaging (MRI) scans of the brain were obtained for six months from seven patients with mildly-disabling relapsing-remitting multiple sclerosis (MS) and seven patients with secondary progressive MS and severe disability. At entry and one year later, two unenhanced T2weighted scans of the brain were also obtained. Despite both the groups were clinically active and presented similar increases of unenhanced MRI lesion load, the total number of enhancing lesions was 243 (42 were on the baseline scans; 136 were new and 65 persistent during follow up) in patients with relapsing-remitting MS (average lesion number/patient/year=69) and 21 (5 were on the baseline scans; 13 were new and 3 persistent during follow up) in those with secondary progressive MS (average lesion number/patient/year=6.6) (p=0.001). Our data indicate that the rate of enhancement significantly decreases in the more advanced phases of MS. This is important when planning clinical trials and suggests that mechanisms underlying lesion formation might be different in different MS patient groups.

Original languageEnglish
Pages (from-to)40
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume18
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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