Serial optical coherence tomography imaging of ACS-causing culprit plaques

Géraud Souteyrand, Eloisa Arbustini, Pascal Motreff, Laura Gatto, Luca Di Vito, Valeria Marco, Nicolas Amabile, Alberto Chisari, Takhaide Kodama, Enrico Romagnoli, Luigi Tavazzi, Filippo Crea, Jagat Narula, Francesco Prati

Research output: Contribution to journalArticle

Abstract

Aims: The aim of this study was to understand better the mechanisms of repair of plaque complications causing acute coronary syndrome. Methods and results: We used OCT in the acute phase and at follow-up (one to seven months) to investigate the plaque healing in 10 culprit plaques: five ruptured fibrous cap (RFC) and five intact fibrous cap (IFC) which were not treated with stent deployment and caused ST-segment elevation myocardial infarction (n=8) and non-STEMI (n=2). At follow-up OCT, the margins of the evacuated cavity in RFC plaques showed a smooth surface and a morphology similar to that of baseline images, while IFC plaques showed a smoothened intimal border and a double layering indicating organising thrombus incorporated in the superficial layers of the plaque. Conclusions: In the months following a successfully dissolved acute thrombosis, OCT revealed that the cavity of RFC plaques persists and is bordered by a smooth "neointima", while IFC plaques showed features suggesting partial incorporation of the deepest layers of thrombus in the plaque.

Original languageEnglish
Pages (from-to)319-324
Number of pages6
JournalEuroIntervention
Volume11
Issue number3
DOIs
Publication statusPublished - Jul 1 2015

Fingerprint

Optical Coherence Tomography
Thrombosis
Tunica Intima
Neointima
Acute Coronary Syndrome
Stents

Keywords

  • Acute coronary syndrome
  • Optical coherence tomography
  • Plaque erosion
  • Plaque rupture

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Souteyrand, G., Arbustini, E., Motreff, P., Gatto, L., Di Vito, L., Marco, V., ... Prati, F. (2015). Serial optical coherence tomography imaging of ACS-causing culprit plaques. EuroIntervention, 11(3), 319-324. https://doi.org/10.4244/EIJV11I3A59

Serial optical coherence tomography imaging of ACS-causing culprit plaques. / Souteyrand, Géraud; Arbustini, Eloisa; Motreff, Pascal; Gatto, Laura; Di Vito, Luca; Marco, Valeria; Amabile, Nicolas; Chisari, Alberto; Kodama, Takhaide; Romagnoli, Enrico; Tavazzi, Luigi; Crea, Filippo; Narula, Jagat; Prati, Francesco.

In: EuroIntervention, Vol. 11, No. 3, 01.07.2015, p. 319-324.

Research output: Contribution to journalArticle

Souteyrand, G, Arbustini, E, Motreff, P, Gatto, L, Di Vito, L, Marco, V, Amabile, N, Chisari, A, Kodama, T, Romagnoli, E, Tavazzi, L, Crea, F, Narula, J & Prati, F 2015, 'Serial optical coherence tomography imaging of ACS-causing culprit plaques', EuroIntervention, vol. 11, no. 3, pp. 319-324. https://doi.org/10.4244/EIJV11I3A59
Souteyrand, Géraud ; Arbustini, Eloisa ; Motreff, Pascal ; Gatto, Laura ; Di Vito, Luca ; Marco, Valeria ; Amabile, Nicolas ; Chisari, Alberto ; Kodama, Takhaide ; Romagnoli, Enrico ; Tavazzi, Luigi ; Crea, Filippo ; Narula, Jagat ; Prati, Francesco. / Serial optical coherence tomography imaging of ACS-causing culprit plaques. In: EuroIntervention. 2015 ; Vol. 11, No. 3. pp. 319-324.
@article{007eab0047c74d0dac20ae666c311cd2,
title = "Serial optical coherence tomography imaging of ACS-causing culprit plaques",
abstract = "Aims: The aim of this study was to understand better the mechanisms of repair of plaque complications causing acute coronary syndrome. Methods and results: We used OCT in the acute phase and at follow-up (one to seven months) to investigate the plaque healing in 10 culprit plaques: five ruptured fibrous cap (RFC) and five intact fibrous cap (IFC) which were not treated with stent deployment and caused ST-segment elevation myocardial infarction (n=8) and non-STEMI (n=2). At follow-up OCT, the margins of the evacuated cavity in RFC plaques showed a smooth surface and a morphology similar to that of baseline images, while IFC plaques showed a smoothened intimal border and a double layering indicating organising thrombus incorporated in the superficial layers of the plaque. Conclusions: In the months following a successfully dissolved acute thrombosis, OCT revealed that the cavity of RFC plaques persists and is bordered by a smooth {"}neointima{"}, while IFC plaques showed features suggesting partial incorporation of the deepest layers of thrombus in the plaque.",
keywords = "Acute coronary syndrome, Optical coherence tomography, Plaque erosion, Plaque rupture",
author = "G{\'e}raud Souteyrand and Eloisa Arbustini and Pascal Motreff and Laura Gatto and {Di Vito}, Luca and Valeria Marco and Nicolas Amabile and Alberto Chisari and Takhaide Kodama and Enrico Romagnoli and Luigi Tavazzi and Filippo Crea and Jagat Narula and Francesco Prati",
year = "2015",
month = "7",
day = "1",
doi = "10.4244/EIJV11I3A59",
language = "English",
volume = "11",
pages = "319--324",
journal = "EuroIntervention",
issn = "1774-024X",
publisher = "EuroPCR",
number = "3",

}

TY - JOUR

T1 - Serial optical coherence tomography imaging of ACS-causing culprit plaques

AU - Souteyrand, Géraud

AU - Arbustini, Eloisa

AU - Motreff, Pascal

AU - Gatto, Laura

AU - Di Vito, Luca

AU - Marco, Valeria

AU - Amabile, Nicolas

AU - Chisari, Alberto

AU - Kodama, Takhaide

AU - Romagnoli, Enrico

AU - Tavazzi, Luigi

AU - Crea, Filippo

AU - Narula, Jagat

AU - Prati, Francesco

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Aims: The aim of this study was to understand better the mechanisms of repair of plaque complications causing acute coronary syndrome. Methods and results: We used OCT in the acute phase and at follow-up (one to seven months) to investigate the plaque healing in 10 culprit plaques: five ruptured fibrous cap (RFC) and five intact fibrous cap (IFC) which were not treated with stent deployment and caused ST-segment elevation myocardial infarction (n=8) and non-STEMI (n=2). At follow-up OCT, the margins of the evacuated cavity in RFC plaques showed a smooth surface and a morphology similar to that of baseline images, while IFC plaques showed a smoothened intimal border and a double layering indicating organising thrombus incorporated in the superficial layers of the plaque. Conclusions: In the months following a successfully dissolved acute thrombosis, OCT revealed that the cavity of RFC plaques persists and is bordered by a smooth "neointima", while IFC plaques showed features suggesting partial incorporation of the deepest layers of thrombus in the plaque.

AB - Aims: The aim of this study was to understand better the mechanisms of repair of plaque complications causing acute coronary syndrome. Methods and results: We used OCT in the acute phase and at follow-up (one to seven months) to investigate the plaque healing in 10 culprit plaques: five ruptured fibrous cap (RFC) and five intact fibrous cap (IFC) which were not treated with stent deployment and caused ST-segment elevation myocardial infarction (n=8) and non-STEMI (n=2). At follow-up OCT, the margins of the evacuated cavity in RFC plaques showed a smooth surface and a morphology similar to that of baseline images, while IFC plaques showed a smoothened intimal border and a double layering indicating organising thrombus incorporated in the superficial layers of the plaque. Conclusions: In the months following a successfully dissolved acute thrombosis, OCT revealed that the cavity of RFC plaques persists and is bordered by a smooth "neointima", while IFC plaques showed features suggesting partial incorporation of the deepest layers of thrombus in the plaque.

KW - Acute coronary syndrome

KW - Optical coherence tomography

KW - Plaque erosion

KW - Plaque rupture

UR - http://www.scopus.com/inward/record.url?scp=84929997018&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929997018&partnerID=8YFLogxK

U2 - 10.4244/EIJV11I3A59

DO - 10.4244/EIJV11I3A59

M3 - Article

C2 - 26196754

AN - SCOPUS:84929997018

VL - 11

SP - 319

EP - 324

JO - EuroIntervention

JF - EuroIntervention

SN - 1774-024X

IS - 3

ER -