Abstract
Aims: The aim of this study was to understand better the mechanisms of repair of plaque complications causing acute coronary syndrome. Methods and results: We used OCT in the acute phase and at follow-up (one to seven months) to investigate the plaque healing in 10 culprit plaques: five ruptured fibrous cap (RFC) and five intact fibrous cap (IFC) which were not treated with stent deployment and caused ST-segment elevation myocardial infarction (n=8) and non-STEMI (n=2). At follow-up OCT, the margins of the evacuated cavity in RFC plaques showed a smooth surface and a morphology similar to that of baseline images, while IFC plaques showed a smoothened intimal border and a double layering indicating organising thrombus incorporated in the superficial layers of the plaque. Conclusions: In the months following a successfully dissolved acute thrombosis, OCT revealed that the cavity of RFC plaques persists and is bordered by a smooth "neointima", while IFC plaques showed features suggesting partial incorporation of the deepest layers of thrombus in the plaque.
| Original language | English |
|---|---|
| Pages (from-to) | 319-324 |
| Number of pages | 6 |
| Journal | EuroIntervention |
| Volume | 11 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jul 1 2015 |
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Keywords
- Acute coronary syndrome
- Optical coherence tomography
- Plaque erosion
- Plaque rupture
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Serial optical coherence tomography imaging of ACS-causing culprit plaques. / Souteyrand, Géraud; Arbustini, Eloisa; Motreff, Pascal; Gatto, Laura; Di Vito, Luca; Marco, Valeria; Amabile, Nicolas; Chisari, Alberto; Kodama, Takhaide; Romagnoli, Enrico; Tavazzi, Luigi; Crea, Filippo; Narula, Jagat; Prati, Francesco.
In: EuroIntervention, Vol. 11, No. 3, 01.07.2015, p. 319-324.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serial optical coherence tomography imaging of ACS-causing culprit plaques
AU - Souteyrand, Géraud
AU - Arbustini, Eloisa
AU - Motreff, Pascal
AU - Gatto, Laura
AU - Di Vito, Luca
AU - Marco, Valeria
AU - Amabile, Nicolas
AU - Chisari, Alberto
AU - Kodama, Takhaide
AU - Romagnoli, Enrico
AU - Tavazzi, Luigi
AU - Crea, Filippo
AU - Narula, Jagat
AU - Prati, Francesco
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Aims: The aim of this study was to understand better the mechanisms of repair of plaque complications causing acute coronary syndrome. Methods and results: We used OCT in the acute phase and at follow-up (one to seven months) to investigate the plaque healing in 10 culprit plaques: five ruptured fibrous cap (RFC) and five intact fibrous cap (IFC) which were not treated with stent deployment and caused ST-segment elevation myocardial infarction (n=8) and non-STEMI (n=2). At follow-up OCT, the margins of the evacuated cavity in RFC plaques showed a smooth surface and a morphology similar to that of baseline images, while IFC plaques showed a smoothened intimal border and a double layering indicating organising thrombus incorporated in the superficial layers of the plaque. Conclusions: In the months following a successfully dissolved acute thrombosis, OCT revealed that the cavity of RFC plaques persists and is bordered by a smooth "neointima", while IFC plaques showed features suggesting partial incorporation of the deepest layers of thrombus in the plaque.
AB - Aims: The aim of this study was to understand better the mechanisms of repair of plaque complications causing acute coronary syndrome. Methods and results: We used OCT in the acute phase and at follow-up (one to seven months) to investigate the plaque healing in 10 culprit plaques: five ruptured fibrous cap (RFC) and five intact fibrous cap (IFC) which were not treated with stent deployment and caused ST-segment elevation myocardial infarction (n=8) and non-STEMI (n=2). At follow-up OCT, the margins of the evacuated cavity in RFC plaques showed a smooth surface and a morphology similar to that of baseline images, while IFC plaques showed a smoothened intimal border and a double layering indicating organising thrombus incorporated in the superficial layers of the plaque. Conclusions: In the months following a successfully dissolved acute thrombosis, OCT revealed that the cavity of RFC plaques persists and is bordered by a smooth "neointima", while IFC plaques showed features suggesting partial incorporation of the deepest layers of thrombus in the plaque.
KW - Acute coronary syndrome
KW - Optical coherence tomography
KW - Plaque erosion
KW - Plaque rupture
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UR - http://www.scopus.com/inward/citedby.url?scp=84929997018&partnerID=8YFLogxK
U2 - 10.4244/EIJV11I3A59
DO - 10.4244/EIJV11I3A59
M3 - Article
C2 - 26196754
AN - SCOPUS:84929997018
VL - 11
SP - 319
EP - 324
JO - EuroIntervention
JF - EuroIntervention
SN - 1774-024X
IS - 3
ER -