Serial optical coherence tomography imaging of ACS-causing culprit plaques

Géraud Souteyrand, Eloisa Arbustini, Pascal Motreff, Laura Gatto, Luca Di Vito, Valeria Marco, Nicolas Amabile, Alberto Chisari, Takhaide Kodama, Enrico Romagnoli, Luigi Tavazzi, Filippo Crea, Jagat Narula, Francesco Prati

Research output: Contribution to journalArticlepeer-review


Aims: The aim of this study was to understand better the mechanisms of repair of plaque complications causing acute coronary syndrome. Methods and results: We used OCT in the acute phase and at follow-up (one to seven months) to investigate the plaque healing in 10 culprit plaques: five ruptured fibrous cap (RFC) and five intact fibrous cap (IFC) which were not treated with stent deployment and caused ST-segment elevation myocardial infarction (n=8) and non-STEMI (n=2). At follow-up OCT, the margins of the evacuated cavity in RFC plaques showed a smooth surface and a morphology similar to that of baseline images, while IFC plaques showed a smoothened intimal border and a double layering indicating organising thrombus incorporated in the superficial layers of the plaque. Conclusions: In the months following a successfully dissolved acute thrombosis, OCT revealed that the cavity of RFC plaques persists and is bordered by a smooth "neointima", while IFC plaques showed features suggesting partial incorporation of the deepest layers of thrombus in the plaque.

Original languageEnglish
Pages (from-to)319-324
Number of pages6
Issue number3
Publication statusPublished - Jul 1 2015


  • Acute coronary syndrome
  • Optical coherence tomography
  • Plaque erosion
  • Plaque rupture

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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