Sericins exhibit ROS-scavenging, anti-tyrosinase, anti-elastase, and in vitro immunomodulatory activities

Theodora Chlapanidas, Silvio Faragò, Giulia Lucconi, Sara Perteghella, Marta Galuzzi, Melissa Mantelli, Maria Antonietta Avanzini, Marta Cecilia Tosca, Mario Marazzi, Daniele Vigo, Maria Luisa Torre, Massimo Faustini

Research output: Contribution to journalArticlepeer-review


Some biological properties of Bombyx mori sericins from twenty strains were investigated, fourteen fed with artificial diet, two with fresh mulberry leaves and four with both diets. Sericin exhibited ROS-scavenging, anti-tyrosinase and anti-elastase properties, the strain significantly influenced these properties, while diet only influenced the anti-tyrosinase activity. Sericins were clustered into 5 groups and one sericin from each group was further studied: sericins showed anti-proliferative activity on in vitro stimulated peripheral blood mononuclear cells; some strains decreased in vitro secretion of IFNγ, while no effects were observed on TNFα and IL10 release.Therefore, a mixture of sericins extracted from the most promising strains may be useful for dermatological and cosmetic use.

Original languageEnglish
Pages (from-to)47-56
Number of pages10
JournalInternational Journal of Biological Macromolecules
Publication statusPublished - Jul 2013


  • Anti-elastase activity
  • Anti-IFNγ activity
  • Anti-proliferative activity
  • Anti-tyrosinase activity
  • ROS-scavenging activity
  • Sericin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Structural Biology


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