Serine-O-phosphate, an endogenous metabolite, inhibits the stimulation of inositol phospholipid hydrolysis elicited by ibotenic acid in rat hippocampal slices

F. Nicoletti, J. T. Wroblewski, M. J. Iadarola, E. Costa

Research output: Contribution to journalArticlepeer-review

Abstract

Serine-O-phosphate (PS) inhibits the accumulation of 3H-inositolmonophosphate elicited by ibotenic acid in rat hippocampal slices incubated in the presence of 7 mM Li+. This inhibition is concentration- dependent and stereoselective, L-PS being 5 fold more potent than D-PS. Among different structural analogues of PS, only L-serine weakly antagonizes the action of ibotenic acid, whereas phosphorylcholine, phosphorylethanolamine and phosphothreonine are inactive even at high concentrations. These results are consistent with the hypothesis that L-PS may act as an endogenous regulator of excitatory amino acid receptor function.

Original languageEnglish
Pages (from-to)335-338
Number of pages4
JournalNeuropharmacology
Volume25
Issue number3
DOIs
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

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