Abstract
Serine-O-phosphate (PS) inhibits the accumulation of 3H-inositolmonophosphate elicited by ibotenic acid in rat hippocampal slices incubated in the presence of 7 mM Li+. This inhibition is concentration- dependent and stereoselective, L-PS being 5 fold more potent than D-PS. Among different structural analogues of PS, only L-serine weakly antagonizes the action of ibotenic acid, whereas phosphorylcholine, phosphorylethanolamine and phosphothreonine are inactive even at high concentrations. These results are consistent with the hypothesis that L-PS may act as an endogenous regulator of excitatory amino acid receptor function.
| Original language | English |
|---|---|
| Pages (from-to) | 335-338 |
| Number of pages | 4 |
| Journal | Neuropharmacology |
| Volume | 25 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1986 |
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ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Drug Discovery
- Pharmacology
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Serine-O-phosphate, an endogenous metabolite, inhibits the stimulation of inositol phospholipid hydrolysis elicited by ibotenic acid in rat hippocampal slices. / Nicoletti, F.; Wroblewski, J. T.; Iadarola, M. J.; Costa, E.
In: Neuropharmacology, Vol. 25, No. 3, 1986, p. 335-338.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serine-O-phosphate, an endogenous metabolite, inhibits the stimulation of inositol phospholipid hydrolysis elicited by ibotenic acid in rat hippocampal slices
AU - Nicoletti, F.
AU - Wroblewski, J. T.
AU - Iadarola, M. J.
AU - Costa, E.
PY - 1986
Y1 - 1986
N2 - Serine-O-phosphate (PS) inhibits the accumulation of 3H-inositolmonophosphate elicited by ibotenic acid in rat hippocampal slices incubated in the presence of 7 mM Li+. This inhibition is concentration- dependent and stereoselective, L-PS being 5 fold more potent than D-PS. Among different structural analogues of PS, only L-serine weakly antagonizes the action of ibotenic acid, whereas phosphorylcholine, phosphorylethanolamine and phosphothreonine are inactive even at high concentrations. These results are consistent with the hypothesis that L-PS may act as an endogenous regulator of excitatory amino acid receptor function.
AB - Serine-O-phosphate (PS) inhibits the accumulation of 3H-inositolmonophosphate elicited by ibotenic acid in rat hippocampal slices incubated in the presence of 7 mM Li+. This inhibition is concentration- dependent and stereoselective, L-PS being 5 fold more potent than D-PS. Among different structural analogues of PS, only L-serine weakly antagonizes the action of ibotenic acid, whereas phosphorylcholine, phosphorylethanolamine and phosphothreonine are inactive even at high concentrations. These results are consistent with the hypothesis that L-PS may act as an endogenous regulator of excitatory amino acid receptor function.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022648948&partnerID=8YFLogxK
U2 - 10.1016/0028-3908(86)90262-5
DO - 10.1016/0028-3908(86)90262-5
M3 - Article
C2 - 3084992
AN - SCOPUS:0022648948
VL - 25
SP - 335
EP - 338
JO - Neuropharmacology
JF - Neuropharmacology
SN - 0028-3908
IS - 3
ER -