Seroepidemiologic study of human coronavirus OC43 infections in Italy.

G. Gerna, E. Cattaneo, P. Cereda, M. G. Revello

Research output: Contribution to journalArticlepeer-review


Human Coronavirus OC43 from suckling mouse brain (SMB) suspension has been adapted to grow in human embryonic lung fibroblast cell cultures. Complement-fixing and hemagglutinating antigens were prepared from infected cell cultures and used in parallel with the same antigens from SMB for a study of the prevalence of OC43 antibody in Northern Italy as well as for the serodiagnosis of recent OC43 infections and reinfections. Results show (i) a higher sensitivity of the hemagglutination-inhibition as compared to the complement fixation test both for antibody detection in seroepidemiological studies and serodiagnosis of acute infections, (ii) a high prevalence of OC43 antibody in Northern Italy, so that only exceptionally are people older than 12 years seronegative, (iii) a high rate of OC43 reinfections during the winter-spring season 1976/77 in a population sample with preexisting antibody (iv) a good quality of reagents prepared from cell cultures, and hence free of contaminating mouse viruses, such as mouse hepatitis virus.

Original languageEnglish
Pages (from-to)535-542
Number of pages8
JournalBollettino dell'Istituto Sieroterapico Milanese
Issue number4
Publication statusPublished - Sep 30 1978

ASJC Scopus subject areas

  • Immunology


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