Serologic investigation of undifferentiated nasopharyngeal carcinoma and simian virus 40 infection

Elisa Mazzoni, Fernanda Martini, Alfredo Corallini, Angelo Taronna, Giuseppe Barbanti-Brodano, Patrizia Querzoli, Eros Magri, John Charles Rotondo, Riccardo Dolcetti, Emanuela Vaccher, Mauro Tognon

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background The association between undifferentiated nasopharyngeal carcinoma (NPC) and Epstein-Barr virus (EBV) is well established. Nevertheless, available evidence suggests that other cofactors are required for the development of undifferentiated NPC. Several investigations reported simian virus 40 (SV40) footprints in human tumors of different histotypes. Methods Serum samples from patients with undifferentiated NPC (n = 64) and healthy subjects (n = 130) were analyzed by an indirect enzyme-linked immunosorbent assay (ELISA) with SV40 synthetic peptides to detect antibodies against viral peptide (VP) capsid proteins VP1, 2, and 3. Results Immunologic data indicate that in sera from patients with undifferentiated NPC, the prevalence of SV40 antibodies was 25%, whereas in controls it was 16%. This difference is not statistically significant (p >.05). Conclusion A similar prevalence of SV40 antibodies was detected in undifferentiated NPC and healthy subjects. Our serologic data suggest no association between undifferentiated NPC and SV40 infection. This investigation may stimulate further studies aimed at determining the possible contribution of other risk factors in the pathogenesis of undifferentiated NPC.

Original languageEnglish
Pages (from-to)232-236
Number of pages5
JournalHead and Neck
Volume38
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Fingerprint

Simian virus 40
Virus Diseases
Carcinoma
Healthy Volunteers
Viral Antibodies
Peptides
Antibodies
Capsid Proteins
Nasopharyngeal carcinoma
Serum
Human Herpesvirus 4
Enzyme-Linked Immunosorbent Assay
Neoplasms

Keywords

  • antibody
  • enzyme-linked immunosorbent assay (ELISA)
  • simian virus 40
  • undifferentiated nasopharyngeal carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Mazzoni, E., Martini, F., Corallini, A., Taronna, A., Barbanti-Brodano, G., Querzoli, P., ... Tognon, M. (2016). Serologic investigation of undifferentiated nasopharyngeal carcinoma and simian virus 40 infection. Head and Neck, 38(2), 232-236. https://doi.org/10.1002/hed.23879

Serologic investigation of undifferentiated nasopharyngeal carcinoma and simian virus 40 infection. / Mazzoni, Elisa; Martini, Fernanda; Corallini, Alfredo; Taronna, Angelo; Barbanti-Brodano, Giuseppe; Querzoli, Patrizia; Magri, Eros; Rotondo, John Charles; Dolcetti, Riccardo; Vaccher, Emanuela; Tognon, Mauro.

In: Head and Neck, Vol. 38, No. 2, 01.02.2016, p. 232-236.

Research output: Contribution to journalArticle

Mazzoni, E, Martini, F, Corallini, A, Taronna, A, Barbanti-Brodano, G, Querzoli, P, Magri, E, Rotondo, JC, Dolcetti, R, Vaccher, E & Tognon, M 2016, 'Serologic investigation of undifferentiated nasopharyngeal carcinoma and simian virus 40 infection', Head and Neck, vol. 38, no. 2, pp. 232-236. https://doi.org/10.1002/hed.23879
Mazzoni E, Martini F, Corallini A, Taronna A, Barbanti-Brodano G, Querzoli P et al. Serologic investigation of undifferentiated nasopharyngeal carcinoma and simian virus 40 infection. Head and Neck. 2016 Feb 1;38(2):232-236. https://doi.org/10.1002/hed.23879
Mazzoni, Elisa ; Martini, Fernanda ; Corallini, Alfredo ; Taronna, Angelo ; Barbanti-Brodano, Giuseppe ; Querzoli, Patrizia ; Magri, Eros ; Rotondo, John Charles ; Dolcetti, Riccardo ; Vaccher, Emanuela ; Tognon, Mauro. / Serologic investigation of undifferentiated nasopharyngeal carcinoma and simian virus 40 infection. In: Head and Neck. 2016 ; Vol. 38, No. 2. pp. 232-236.
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