Serologic investigation of undifferentiated nasopharyngeal carcinoma and simian virus 40 infection

Elisa Mazzoni, Fernanda Martini, Alfredo Corallini, Angelo Taronna, Giuseppe Barbanti-Brodano, Patrizia Querzoli, Eros Magri, John Charles Rotondo, Riccardo Dolcetti, Emanuela Vaccher, Mauro Tognon

Research output: Contribution to journalArticle

Abstract

Background The association between undifferentiated nasopharyngeal carcinoma (NPC) and Epstein-Barr virus (EBV) is well established. Nevertheless, available evidence suggests that other cofactors are required for the development of undifferentiated NPC. Several investigations reported simian virus 40 (SV40) footprints in human tumors of different histotypes. Methods Serum samples from patients with undifferentiated NPC (n = 64) and healthy subjects (n = 130) were analyzed by an indirect enzyme-linked immunosorbent assay (ELISA) with SV40 synthetic peptides to detect antibodies against viral peptide (VP) capsid proteins VP1, 2, and 3. Results Immunologic data indicate that in sera from patients with undifferentiated NPC, the prevalence of SV40 antibodies was 25%, whereas in controls it was 16%. This difference is not statistically significant (p >.05). Conclusion A similar prevalence of SV40 antibodies was detected in undifferentiated NPC and healthy subjects. Our serologic data suggest no association between undifferentiated NPC and SV40 infection. This investigation may stimulate further studies aimed at determining the possible contribution of other risk factors in the pathogenesis of undifferentiated NPC.

Original languageEnglish
Pages (from-to)232-236
Number of pages5
JournalHead and Neck
Volume38
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Keywords

  • antibody
  • enzyme-linked immunosorbent assay (ELISA)
  • simian virus 40
  • undifferentiated nasopharyngeal carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology

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    Mazzoni, E., Martini, F., Corallini, A., Taronna, A., Barbanti-Brodano, G., Querzoli, P., Magri, E., Rotondo, J. C., Dolcetti, R., Vaccher, E., & Tognon, M. (2016). Serologic investigation of undifferentiated nasopharyngeal carcinoma and simian virus 40 infection. Head and Neck, 38(2), 232-236. https://doi.org/10.1002/hed.23879