Recent evidence has been produced that supports the role of hepatitis C virus in the pathogenesis of autoimmune chronic hepatitis (ACH) developing in patients with lichen planus (LP). We report the results of a serological study performed on a group of 61 LP patients, 21 of whom also had a chronic liver disorder. The following antibodies were studied: antinuclear (ANA), anti-smooth muscle (SM) (actin), anti-liver-kidney microsome (LKM1), antisoluble liver antigen (SLA), anti-GOR and anti-mitochondria (M2). Our patients were all anti-M2 and anti-LKM-1 negative, had anti-GOR in about 14% of cases and anti-SLA in only one case. As expected, all anti-GOR-positive patients were also anti-hepatitis C virus (HCV)-positive. These findings suggest that in countries with high HCV circulation, ACH) overlaps post-HCV-hepatitis and that LP patients develop ACH)) type 2b not differing in that from other Italian patients with hepatitis without LP.
|Number of pages||2|
|Journal||European Journal of Dermatology|
|Publication status||Published - 1996|
- Hepatitis C virus
- Lichen planus
ASJC Scopus subject areas