Serologic markers of autoimmune chronic hepatitis in patients with lichen planus

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Abstract

Recent evidence has been produced that supports the role of hepatitis C virus in the pathogenesis of autoimmune chronic hepatitis (ACH) developing in patients with lichen planus (LP). We report the results of a serological study performed on a group of 61 LP patients, 21 of whom also had a chronic liver disorder. The following antibodies were studied: antinuclear (ANA), anti-smooth muscle (SM) (actin), anti-liver-kidney microsome (LKM1), antisoluble liver antigen (SLA), anti-GOR and anti-mitochondria (M2). Our patients were all anti-M2 and anti-LKM-1 negative, had anti-GOR in about 14% of cases and anti-SLA in only one case. As expected, all anti-GOR-positive patients were also anti-hepatitis C virus (HCV)-positive. These findings suggest that in countries with high HCV circulation, ACH) overlaps post-HCV-hepatitis and that LP patients develop ACH)) type 2b not differing in that from other Italian patients with hepatitis without LP.

Original languageEnglish
Pages (from-to)30-31
Number of pages2
JournalEuropean Journal of Dermatology
Volume6
Issue number1
Publication statusPublished - 1996

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Keywords

  • Hepatitis C virus
  • Lichen planus

ASJC Scopus subject areas

  • Dermatology

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