Serologic survey for control of hepatitis C in haemodialysis patients: Third-generation assays and analysis of costs

F. Fabrizi, G. Lunghi, L. Raffaele, I. Guarnori, G. Bacchini, M. Corti, A. Pagano, G. Erba, F. Locatelli

Research output: Contribution to journalArticlepeer-review

Abstract

There is little information about the serologic survey for control of hepatitis C by using third-generation assays among chronic haemodialysis (HD) patients, and no analysis of costs has been made to this end. A serologic survey for control of hepatitis C was performed in 190 HD patients attending a single dialysis unit, using second- and third-generation assays. Costs of both serologic surveys were calculated. Anti-HCV prevalence tested by third-generation assays increased from 25% (48/190) to 28% (53/190) compared to second-generation testing; 56% (9/16) of patients showing uncertain findings by second-generation tests gave unequivocal results by third-generation assays; median duration of HD treatment and raised aminotransferase levels were positively associated (P = 0.004 and P = 0.012, respectively) with anti-HCV detected by third-generation assays. The serologic survey for control of hepatitis C in HD patients at our centre was slightly more expensive by third-generation assays compared to second-generation testing (US$ 18,866 vs US$ 17,200 per year). In summary, the use of third-generation tests largely clarified the uncertain results of second-generation tests; new additional positive patients were detected by third-generation assays compared to second-generation testing. Third-generation assays showed the association of duration of HD treatment and raised aminotransferase levels with anti-HCV antibody, as previously found by first- and second-generation assays. To date, third-generation screening and confirmatory assays seem extremely useful in the serologic survey for control of hepatitis C in HD centres without a considerable outlay.

Original languageEnglish
Pages (from-to)298-303
Number of pages6
JournalNephrology Dialysis Transplantation
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 1997

Keywords

  • Analysis of costs
  • Haemodialysis patients
  • Third-generation HCV confirmatory assays
  • Third-generation HCV screening assays

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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