Granulomatosi di Wegener in fase acuta iniziale: Aspetti clinici e sierologici

Translated title of the contribution: Serological and clinical aspects in initial Wegener's disease. A case report

Caterina Defendenti, Giacinto Guercilena, Angela Freschi, Anna Maria Croce, Federica Servida, Silvia Russo, Silvia Grosso, Margherita Longo, Maria Francesca Spina, Antonio Miadonna, Fabiola Atzeni, Piercarlo Sarzi-Puttini

Research output: Contribution to journalArticle

Abstract

The clinical and biochemical features of an acute and initial Wegener's granulomatosis case were analysed in a young woman. A multifactorial aspects are evident. A chronic inflammation of the superior respiratory tract has been observed. Staphylococcus aureus has been isolated. An oligoclonal component constituted of high levels of anti-PR3 autoantibodies was detected: initial autoreactive B cell clone activation is probable. The chronological link with postpartum is present: our study excluded foetal microchimerism; the hormonal state can be a trigger factor. Serical IL-17 was negative.

Translated title of the contributionSerological and clinical aspects in initial Wegener's disease. A case report
Original languageItalian
Pages (from-to)349-354
Number of pages6
JournalRecenti Progressi in Medicina
Volume101
Issue number9
DOIs
Publication statusPublished - Sep 2010

ASJC Scopus subject areas

  • Medicine(all)

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    Defendenti, C., Guercilena, G., Freschi, A., Croce, A. M., Servida, F., Russo, S., Grosso, S., Longo, M., Spina, M. F., Miadonna, A., Atzeni, F., & Sarzi-Puttini, P. (2010). Granulomatosi di Wegener in fase acuta iniziale: Aspetti clinici e sierologici. Recenti Progressi in Medicina, 101(9), 349-354. https://doi.org/10.1701/515.6146