The clinical and biochemical features of an acute and initial Wegener's granulomatosis case were analysed in a young woman. A multifactorial aspects are evident. A chronic inflammation of the superior respiratory tract has been observed. Staphylococcus aureus has been isolated. An oligoclonal component constituted of high levels of anti-PR3 autoantibodies was detected: initial autoreactive B cell clone activation is probable. The chronological link with postpartum is present: our study excluded foetal microchimerism; the hormonal state can be a trigger factor. Serical IL-17 was negative.
|Translated title of the contribution||Serological and clinical aspects in initial Wegener's disease. A case report|
|Number of pages||6|
|Journal||Recenti Progressi in Medicina|
|Publication status||Published - Sep 2010|
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