TY - JOUR
T1 - Serological and molecular investigation of 2117-like vesiviruses in cats
AU - Di Martino, Barbara
AU - Di Profio, Federica
AU - Melegari, Irene
AU - Sarchese, Vittorio
AU - Massirio, Ivano
AU - Luciani, Alessia
AU - Lanave, Gianvito
AU - Marsilio, Fulvio
AU - Martella, Vito
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Vesivirus 2117 was first discovered as a contaminant in Chinese hamster ovary (CHO) cell cultures used for human drug production. Similar vesiviruses (VeVs) have been detected recently in dogs. In order to address the hypothesis that cats may also be exposed to 2117-like VeVs, in this study, we screened 236 feline sera using an enzyme-linked immunosorbent assay (ELISA) based on a recombinant VP1 protein from the canine VeV Bari/212/07/ITA. IgG antibodies against the 2117-like VeV were detected in 37.3% of the sera tested. Also, by screening cat faecal specimens, the RNA of a 2117-like VeV was detected in a clinically healthy cat.
AB - Vesivirus 2117 was first discovered as a contaminant in Chinese hamster ovary (CHO) cell cultures used for human drug production. Similar vesiviruses (VeVs) have been detected recently in dogs. In order to address the hypothesis that cats may also be exposed to 2117-like VeVs, in this study, we screened 236 feline sera using an enzyme-linked immunosorbent assay (ELISA) based on a recombinant VP1 protein from the canine VeV Bari/212/07/ITA. IgG antibodies against the 2117-like VeV were detected in 37.3% of the sera tested. Also, by screening cat faecal specimens, the RNA of a 2117-like VeV was detected in a clinically healthy cat.
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U2 - 10.1007/s00705-017-3582-z
DO - 10.1007/s00705-017-3582-z
M3 - Article
C2 - 29022118
AN - SCOPUS:85031122221
VL - 163
SP - 197
EP - 201
JO - Archives of Virology
JF - Archives of Virology
SN - 0304-8608
IS - 1
ER -