Serological immunoreactivity against colon cancer proteome varies upon disease progression

Lucia De Monte, Francesca Sanvito, Stefano Olivieri, Fiammetta Viganò, Claudio Doglioni, Matteo Frasson, Marco Braga, Angela Bachi, Paolo Dellabona, Maria Pia Protti, Massimo Alessio

Research output: Contribution to journalArticlepeer-review

Abstract

Sera from colon carcinoma patients were used to identify tumor-associated antigens (TAAs) by screening tumor proteome resolved by 2D electrophoresis. A panel of six TAAs eliciting a serological immune response in colorectal cancer was identified, showing a modification in antigen recognition by B cells in patients as a function of colon cancer progression. The expression of these proteins was either confined or increased in tumor as compared to normal mucosa.

Original languageEnglish
Pages (from-to)504-514
Number of pages11
JournalJournal of Proteome Research
Volume7
Issue number2
DOIs
Publication statusPublished - Feb 2008

Keywords

  • 2D electrophoresis
  • Colorectal carcinoma
  • Proteomics
  • Tumor-associated antigens

ASJC Scopus subject areas

  • Genetics
  • Biotechnology
  • Biochemistry

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