Seroprevalence for norovirus genogroups GII and GIV in captive non-human primates

Federica Di Profio, Vittorio Sarchese, Irene Melegari, Andrea Palombieri, Ivano Massirio, Sandra Bermudez Sanchez, Klaus Gunther Friedrich, Federico Coccia, Fulvio Marsilio, Vito Martella, Barbara Di Martino

Research output: Contribution to journalArticle

Abstract

Noroviruses (NoVs) are a major cause of epidemic gastroenteritis in children and adults. Several pieces of evidence suggest that viruses genetically and antigenically closely related to human NoVs might infect animals, raising public health concerns about potential cross-species transmission. The natural susceptibility of non-human primates (NPHs) to human NoV infections has already been reported, but a limited amount of data is currently available. In order to start filling this gap, we screened a total of 86 serum samples of seven different species of NPHs housed at the Zoological Garden (Bioparco) of Rome (Italy), collected between 2001 and 2017, using an enzyme-linked immunosorbent assay (ELISA) based on virus-like particles (VLPs) of human GII.4 and GIV.1 NoVs. Antibodies specific for both genotypes were detected with an overall prevalence of 32.6%. In detail, IgG antibodies against GII.4 NoVs were found in 18 Japanese macaques (29.0%, 18/62), a mandrill (10.0%, 1/10), a white-crowned mangabey (16.6%, 1/6) and in an orangutan (33.3%, 1/3). Twelve macaques (19.3%, 12/62), five mandrills (50.0%, 5/10), two chimpanzees (100%, 2/2) and a white-crowned mangabey (16.6%, 1/6) showed antibodies for GIV.1 NoVs. The findings of this study confirm the natural susceptibility of captive NHPs to GII NoV infections. In addition, IgG antibodies against GIV.1 were detected, suggesting that NHPs are exposed to GIV NoVs or to antigenically related NoV strains.

Original languageEnglish
JournalZoonoses and Public Health
DOIs
Publication statusPublished - Jan 1 2019
Externally publishedYes

Keywords

  • genotypes GII.4 and GIV.1
  • IgG antibodies
  • non-human primates
  • noroviruses

ASJC Scopus subject areas

  • Epidemiology
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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  • Cite this

    Di Profio, F., Sarchese, V., Melegari, I., Palombieri, A., Massirio, I., Bermudez Sanchez, S., Friedrich, K. G., Coccia, F., Marsilio, F., Martella, V., & Di Martino, B. (2019). Seroprevalence for norovirus genogroups GII and GIV in captive non-human primates. Zoonoses and Public Health. https://doi.org/10.1111/zph.12566