Seroprevalence of antibodies to HTLV-I in patients with chronic neurological disorders other than tropical spastic paraparesis

C. A. Mora, R. M. Garruto, P. Brown, D. Guiroy, O. S C Morgan, P. Rodgers-Johnson, M. Ceroni, R. Yanagihara, L. G. Goldfarb, C. J. Gibbs, D. C. Gajdusek

Research output: Contribution to journalArticle

Abstract

Human T-lymphotropic virus type I (HTLV-I), the etiological agent of adult T-cell leukemia/lymphoma, also appears to be the cause of tropical spastic paraparesis, a chronic myelopathy reported in several different regions of the world. The prevalence of antibodies to HTLV-I in patients with chronic neurodegenerative disorders other than tropical spastic paraparesis and in patients with some muscle inflammatory disorders has been investigated. IgG antibodies to HTLV-I were measured in the sera and/or cerebrospinal fluid from 82 Guamanian patients with amyotrophic lateral sclerosis and parkinsonism-dementia, 164 Guamanian normal controls, 10 patients with kuru from the Eastern Highlands of Papua New Guinea, 4 patients with Viliuisk encephalomyelitis from the Iakut region of eastern Siberia, 45 Italian patients with multiple sclerosis, and 56 patients with polymyositis (49 from the United States and 7 from Jamaica). As determined by enzyme-linked immunosorbent assay. Western immunoblot, and gelatin particle agglutination techniques, serological evidence of HTLV-I infection was found in 1 patient with amyotrophic lateral sclerosis and 1 control subject from Guam, and in 1 patient from the United States and all 7 Jamaican patients with polymyositis. Except for the high seropositivity rate among the group of Jamaican patients with polymyositis, our data indicate that HTLV-I is an unlikely causative agent in the spectrum of the neurological diseases examined. The seropositivity of the 7 Jamaican patients with polymyositis requires further study.

Original languageEnglish
JournalAnnals of Neurology
Volume23
Issue numberSUPPL.
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Neuroscience(all)

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    Mora, C. A., Garruto, R. M., Brown, P., Guiroy, D., Morgan, O. S. C., Rodgers-Johnson, P., Ceroni, M., Yanagihara, R., Goldfarb, L. G., Gibbs, C. J., & Gajdusek, D. C. (1988). Seroprevalence of antibodies to HTLV-I in patients with chronic neurological disorders other than tropical spastic paraparesis. Annals of Neurology, 23(SUPPL.).