Seroprevalence of hepatitis A virus and Helicobacter pylori infections in the general population of a developed European country (the San Marino study): Evidence for similar pattern of spread

Stefano Pretolani, Tommaso Stroffolini, Mariella Rapicetta, Fiorenza Bonvicini, Lorenzo Baldini, Francis Mègraud, Gian Carlo Ghironzi, Francesca Sampogna, Umbertina Villano, Fernando Cecchetti, Giuliana Giulianelli, Maria Loredana Stefanelli, Alessandro Armuzzi, Federico Miglio, Giovanni Gasbarrini

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate the role of faecal-oral transmission in the spread of Helicobacter pylori. Design: A cross-sectional comparison of the patterns of hepatitis A and H. pylori seropositivity. Methods: At interview, blood samples and questionnaire data were collected from a random sample of 1528 healthy subjects aged 20-85 years from the Republic of San Marino. Serum samples from each subject were then tested for anti-H. pylori and anti-hepatitis A antibodies. Results: Overall, 529 of 670 H. pylori-seropositive subjects (78.9%) and 460 of 858 H. pylori-seronegative subjects (53.6%) were hepatitis A seropositive (P <0.01; odds ratio = 3.2; confidence interval 95% = 2.6-4.1). This association remained after adjustment by a multiple logistic regression analysis for the confounding effect of age and length of schooling, as surrogate for socio-economic status (OR = 2.0; CI 95% = 1.3-3.3). The age-specific prevalence curves for H. pylori and hepatitis A infections showed a parallel increase by age, although to a lesser extent for H. pylori. Conclusion: These findings provide evidence that in the community studied H. pylori may have spread in a manner similar to that of hepatitis A.

Original languageEnglish
Pages (from-to)1081-1084
Number of pages4
JournalEuropean Journal of Gastroenterology and Hepatology
Volume9
Issue number11
Publication statusPublished - 1997

Keywords

  • Helicobacter pylori
  • Hepatitis A
  • Transmission

ASJC Scopus subject areas

  • Gastroenterology

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