Seroprevalence of herpes simplex virus type 2 infection among attendees of a sexually transmitted disease clinic in Italy

Marco Cusini, Monica Cusan, Cristina Parolin, Livia Scioccati, Irene Decleva, Carlo Mengoli, Barbara Suligoi, Giorgio Palú

Research output: Contribution to journalArticle

Abstract

Background and Objectives: An increased prevalence of herpes simplex virus type 2 (HSV-2) infection has been recently observed in industrialized countries. Goal: To determine HSV-2 seroprevalence in a high-risk population in Italy. Study Design: A cross-sectional study was performed to ascertain the HSV-2 prevalence among 919 persons attending an STD clinic in northern Italy. A HSV-2-specific glycoprotein G-2-based immunoglobulin G enzyme-linked immunoabsorbent assay (Gull/Meridian ELISA; Meridian Diagnostics, Cincinnati, OH) was used and validated against Western blot analysis. Results: A prevalence of 24.6% was found without differences between males and females. Seroprevalence increased with age and number of partners during the previous year. Compared with Western blot analysis, the Gull/Meridian ELISA showed a sensitivity of 91.9% and a specificity of 98%, and positive and negative predictive values of 93.9% and 97.4%, respectively. Conclusion: This is the first Italian survey of HSV-2 infection conducted with a properly validated, Food and Drug Administration-approved, type-specific serologic method in a high-risk population. It is likely that between one to three million adults are infected with HSV-2.

Original languageEnglish
Pages (from-to)292-295
Number of pages4
JournalSexually Transmitted Diseases
Volume27
Issue number5
Publication statusPublished - May 2000

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)

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