Seroprevalence of herpes simplex virus type 2 infection among attendees of a sexually transmitted disease clinic in Italy

Marco Cusini, Monica Cusan, Cristina Parolin, Livia Scioccati, Irene Decleva, Carlo Mengoli, Barbara Suligoi, Giorgio Palú

Research output: Contribution to journalArticle

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Abstract

Background and Objectives: An increased prevalence of herpes simplex virus type 2 (HSV-2) infection has been recently observed in industrialized countries. Goal: To determine HSV-2 seroprevalence in a high-risk population in Italy. Study Design: A cross-sectional study was performed to ascertain the HSV-2 prevalence among 919 persons attending an STD clinic in northern Italy. A HSV-2-specific glycoprotein G-2-based immunoglobulin G enzyme-linked immunoabsorbent assay (Gull/Meridian ELISA; Meridian Diagnostics, Cincinnati, OH) was used and validated against Western blot analysis. Results: A prevalence of 24.6% was found without differences between males and females. Seroprevalence increased with age and number of partners during the previous year. Compared with Western blot analysis, the Gull/Meridian ELISA showed a sensitivity of 91.9% and a specificity of 98%, and positive and negative predictive values of 93.9% and 97.4%, respectively. Conclusion: This is the first Italian survey of HSV-2 infection conducted with a properly validated, Food and Drug Administration-approved, type-specific serologic method in a high-risk population. It is likely that between one to three million adults are infected with HSV-2.

Original languageEnglish
Pages (from-to)292-295
Number of pages4
JournalSexually Transmitted Diseases
Volume27
Issue number5
Publication statusPublished - May 2000

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Human Herpesvirus 2
Seroepidemiologic Studies
Virus Diseases
Sexually Transmitted Diseases
Italy
Meridians
Charadriiformes
Western Blotting
Enzyme-Linked Immunosorbent Assay
United States Food and Drug Administration
Developed Countries
Population
Glycoproteins
Cross-Sectional Studies
Immunoglobulin G
Enzymes

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)

Cite this

Cusini, M., Cusan, M., Parolin, C., Scioccati, L., Decleva, I., Mengoli, C., ... Palú, G. (2000). Seroprevalence of herpes simplex virus type 2 infection among attendees of a sexually transmitted disease clinic in Italy. Sexually Transmitted Diseases, 27(5), 292-295.

Seroprevalence of herpes simplex virus type 2 infection among attendees of a sexually transmitted disease clinic in Italy. / Cusini, Marco; Cusan, Monica; Parolin, Cristina; Scioccati, Livia; Decleva, Irene; Mengoli, Carlo; Suligoi, Barbara; Palú, Giorgio.

In: Sexually Transmitted Diseases, Vol. 27, No. 5, 05.2000, p. 292-295.

Research output: Contribution to journalArticle

Cusini, M, Cusan, M, Parolin, C, Scioccati, L, Decleva, I, Mengoli, C, Suligoi, B & Palú, G 2000, 'Seroprevalence of herpes simplex virus type 2 infection among attendees of a sexually transmitted disease clinic in Italy', Sexually Transmitted Diseases, vol. 27, no. 5, pp. 292-295.
Cusini, Marco ; Cusan, Monica ; Parolin, Cristina ; Scioccati, Livia ; Decleva, Irene ; Mengoli, Carlo ; Suligoi, Barbara ; Palú, Giorgio. / Seroprevalence of herpes simplex virus type 2 infection among attendees of a sexually transmitted disease clinic in Italy. In: Sexually Transmitted Diseases. 2000 ; Vol. 27, No. 5. pp. 292-295.
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