Abstract
Objective: To study the seroprevalence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8 (KSHV/ HHV-8) in 779 Italian blood donors. Study Design/Methods: Sera were tested for antibodies to a latency-associated nuclear antigen (LANA) and a capsid related protein encoded by ORF65. Results: Among all Italian donors, 17.7% and 18.7% had antibodies to LANA and ORF65 protein, respectively, and 24.1% had antibodies to at least one antigen. KSHV/HHV-8 seroprevalence was higher in the Po valley and in Sardinia than close to the sub-Alpine Veneto region, Tuscany, or Apulia. KSHV/HHV-8 seroprevalence was almost equally distributed between men and women but increased in the older age groups. Conclusions: The regional differences and age distribution in seroprevalence agree partially with the incidence of classic KS in Italy. The rarity of classic KS in KSHV/HHV-8-infected subjects and the equal gender distribution of seroprevalence suggest that other cofactors may contribute to KS development in human immunodeficiency virus type 1 (HIV-1)-uninfected individuals.
| Original language | English |
|---|---|
| Pages (from-to) | 207-213 |
| Number of pages | 7 |
| Journal | Journal of Human Virology |
| Volume | 1 |
| Issue number | 3 |
| Publication status | Published - Mar 1998 |
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Keywords
- HHV-8
- KSHV
- LANA
- ORF65
- Seroprevalence
ASJC Scopus subject areas
- Virology
Cite this
Seroprevalence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 in several regions of Italy. / Calabrò, M. L.; Sheldon, J.; Favero, A.; Simpson, G. R.; Fiore, J. R.; Gomes, E.; Angarano, G.; Chieco-Bianchi, L.; Schulz, T. F.
In: Journal of Human Virology, Vol. 1, No. 3, 03.1998, p. 207-213.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Seroprevalence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 in several regions of Italy
AU - Calabrò, M. L.
AU - Sheldon, J.
AU - Favero, A.
AU - Simpson, G. R.
AU - Fiore, J. R.
AU - Gomes, E.
AU - Angarano, G.
AU - Chieco-Bianchi, L.
AU - Schulz, T. F.
PY - 1998/3
Y1 - 1998/3
N2 - Objective: To study the seroprevalence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8 (KSHV/ HHV-8) in 779 Italian blood donors. Study Design/Methods: Sera were tested for antibodies to a latency-associated nuclear antigen (LANA) and a capsid related protein encoded by ORF65. Results: Among all Italian donors, 17.7% and 18.7% had antibodies to LANA and ORF65 protein, respectively, and 24.1% had antibodies to at least one antigen. KSHV/HHV-8 seroprevalence was higher in the Po valley and in Sardinia than close to the sub-Alpine Veneto region, Tuscany, or Apulia. KSHV/HHV-8 seroprevalence was almost equally distributed between men and women but increased in the older age groups. Conclusions: The regional differences and age distribution in seroprevalence agree partially with the incidence of classic KS in Italy. The rarity of classic KS in KSHV/HHV-8-infected subjects and the equal gender distribution of seroprevalence suggest that other cofactors may contribute to KS development in human immunodeficiency virus type 1 (HIV-1)-uninfected individuals.
AB - Objective: To study the seroprevalence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8 (KSHV/ HHV-8) in 779 Italian blood donors. Study Design/Methods: Sera were tested for antibodies to a latency-associated nuclear antigen (LANA) and a capsid related protein encoded by ORF65. Results: Among all Italian donors, 17.7% and 18.7% had antibodies to LANA and ORF65 protein, respectively, and 24.1% had antibodies to at least one antigen. KSHV/HHV-8 seroprevalence was higher in the Po valley and in Sardinia than close to the sub-Alpine Veneto region, Tuscany, or Apulia. KSHV/HHV-8 seroprevalence was almost equally distributed between men and women but increased in the older age groups. Conclusions: The regional differences and age distribution in seroprevalence agree partially with the incidence of classic KS in Italy. The rarity of classic KS in KSHV/HHV-8-infected subjects and the equal gender distribution of seroprevalence suggest that other cofactors may contribute to KS development in human immunodeficiency virus type 1 (HIV-1)-uninfected individuals.
KW - HHV-8
KW - KSHV
KW - LANA
KW - ORF65
KW - Seroprevalence
UR - http://www.scopus.com/inward/record.url?scp=0032009941&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032009941&partnerID=8YFLogxK
M3 - Article
C2 - 10195244
AN - SCOPUS:0032009941
VL - 1
SP - 207
EP - 213
JO - Journal of Human Virology
JF - Journal of Human Virology
SN - 1090-9508
IS - 3
ER -