Seroprevalence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 in several regions of Italy

M. L. Calabrò, J. Sheldon, A. Favero, G. R. Simpson, J. R. Fiore, E. Gomes, G. Angarano, L. Chieco-Bianchi, T. F. Schulz

Research output: Contribution to journalArticle

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Abstract

Objective: To study the seroprevalence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8 (KSHV/ HHV-8) in 779 Italian blood donors. Study Design/Methods: Sera were tested for antibodies to a latency-associated nuclear antigen (LANA) and a capsid related protein encoded by ORF65. Results: Among all Italian donors, 17.7% and 18.7% had antibodies to LANA and ORF65 protein, respectively, and 24.1% had antibodies to at least one antigen. KSHV/HHV-8 seroprevalence was higher in the Po valley and in Sardinia than close to the sub-Alpine Veneto region, Tuscany, or Apulia. KSHV/HHV-8 seroprevalence was almost equally distributed between men and women but increased in the older age groups. Conclusions: The regional differences and age distribution in seroprevalence agree partially with the incidence of classic KS in Italy. The rarity of classic KS in KSHV/HHV-8-infected subjects and the equal gender distribution of seroprevalence suggest that other cofactors may contribute to KS development in human immunodeficiency virus type 1 (HIV-1)-uninfected individuals.

Original languageEnglish
Pages (from-to)207-213
Number of pages7
JournalJournal of Human Virology
Volume1
Issue number3
Publication statusPublished - Mar 1998

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Human Herpesvirus 8
Seroepidemiologic Studies
Italy
Antibodies
Age Distribution
Capsid Proteins
Blood Donors
HIV-1
Age Groups
Tissue Donors
Antigens
Incidence

Keywords

  • HHV-8
  • KSHV
  • LANA
  • ORF65
  • Seroprevalence

ASJC Scopus subject areas

  • Virology

Cite this

Calabrò, M. L., Sheldon, J., Favero, A., Simpson, G. R., Fiore, J. R., Gomes, E., ... Schulz, T. F. (1998). Seroprevalence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 in several regions of Italy. Journal of Human Virology, 1(3), 207-213.

Seroprevalence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 in several regions of Italy. / Calabrò, M. L.; Sheldon, J.; Favero, A.; Simpson, G. R.; Fiore, J. R.; Gomes, E.; Angarano, G.; Chieco-Bianchi, L.; Schulz, T. F.

In: Journal of Human Virology, Vol. 1, No. 3, 03.1998, p. 207-213.

Research output: Contribution to journalArticle

Calabrò, ML, Sheldon, J, Favero, A, Simpson, GR, Fiore, JR, Gomes, E, Angarano, G, Chieco-Bianchi, L & Schulz, TF 1998, 'Seroprevalence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 in several regions of Italy', Journal of Human Virology, vol. 1, no. 3, pp. 207-213.
Calabrò, M. L. ; Sheldon, J. ; Favero, A. ; Simpson, G. R. ; Fiore, J. R. ; Gomes, E. ; Angarano, G. ; Chieco-Bianchi, L. ; Schulz, T. F. / Seroprevalence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 in several regions of Italy. In: Journal of Human Virology. 1998 ; Vol. 1, No. 3. pp. 207-213.
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