Seroprevalence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 in several regions of Italy

M. L. Calabrò, J. Sheldon, A. Favero, G. R. Simpson, J. R. Fiore, E. Gomes, G. Angarano, L. Chieco-Bianchi, T. F. Schulz

Research output: Contribution to journalArticlepeer-review


Objective: To study the seroprevalence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8 (KSHV/ HHV-8) in 779 Italian blood donors. Study Design/Methods: Sera were tested for antibodies to a latency-associated nuclear antigen (LANA) and a capsid related protein encoded by ORF65. Results: Among all Italian donors, 17.7% and 18.7% had antibodies to LANA and ORF65 protein, respectively, and 24.1% had antibodies to at least one antigen. KSHV/HHV-8 seroprevalence was higher in the Po valley and in Sardinia than close to the sub-Alpine Veneto region, Tuscany, or Apulia. KSHV/HHV-8 seroprevalence was almost equally distributed between men and women but increased in the older age groups. Conclusions: The regional differences and age distribution in seroprevalence agree partially with the incidence of classic KS in Italy. The rarity of classic KS in KSHV/HHV-8-infected subjects and the equal gender distribution of seroprevalence suggest that other cofactors may contribute to KS development in human immunodeficiency virus type 1 (HIV-1)-uninfected individuals.

Original languageEnglish
Pages (from-to)207-213
Number of pages7
JournalJournal of Human Virology
Issue number3
Publication statusPublished - Mar 1998


  • HHV-8
  • KSHV
  • LANA
  • ORF65
  • Seroprevalence

ASJC Scopus subject areas

  • Virology


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