TY - JOUR
T1 - Serotonergic ergoline derivatives
AU - Mantegani, Sergio
AU - Brambilla, Enzo
AU - Caccia, Carla
AU - Damiani, Gabriele
AU - Fornaretto, Maria Gioia
AU - McArthur, Robert A.
AU - Varasi, Mario
PY - 1998/5
Y1 - 1998/5
N2 - Novel classes of 13- and 14-tertbutyl-ergoline derivatives were prepared, and characterised in vitro for their affinity for adrenergic, dopaminergic and serotonergic binding sites. This study particularly examines the importance of the presence and the position of the tert-butyl group in conferring either significant 5-HT(1A) or 5-HT2 affinity and selectivity respectively.
AB - Novel classes of 13- and 14-tertbutyl-ergoline derivatives were prepared, and characterised in vitro for their affinity for adrenergic, dopaminergic and serotonergic binding sites. This study particularly examines the importance of the presence and the position of the tert-butyl group in conferring either significant 5-HT(1A) or 5-HT2 affinity and selectivity respectively.
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U2 - 10.1016/S0960-894X(98)00166-8
DO - 10.1016/S0960-894X(98)00166-8
M3 - Article
C2 - 9871719
AN - SCOPUS:0032080356
VL - 8
SP - 1117
EP - 1122
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 9
ER -