Serotonergic ergoline derivatives

Sergio Mantegani, Enzo Brambilla, Carla Caccia, Gabriele Damiani, Maria Gioia Fornaretto, Robert A. McArthur, Mario Varasi

Research output: Contribution to journalArticle

Abstract

Novel classes of 13- and 14-tertbutyl-ergoline derivatives were prepared, and characterised in vitro for their affinity for adrenergic, dopaminergic and serotonergic binding sites. This study particularly examines the importance of the presence and the position of the tert-butyl group in conferring either significant 5-HT(1A) or 5-HT2 affinity and selectivity respectively.

Original languageEnglish
Pages (from-to)1117-1122
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number9
DOIs
Publication statusPublished - May 1998

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Mantegani, S., Brambilla, E., Caccia, C., Damiani, G., Fornaretto, M. G., McArthur, R. A., & Varasi, M. (1998). Serotonergic ergoline derivatives. Bioorganic and Medicinal Chemistry Letters, 8(9), 1117-1122. https://doi.org/10.1016/S0960-894X(98)00166-8