Serotonergic ergoline derivatives

Sergio Mantegani; Enzo Brambilla; Carla Caccia; Gabriele Damiani; Maria Gioia Fornaretto; Robert A. McArthur; Mario Varasi

doi:10.1016/S0960-894X(98)00166-8

Serotonergic ergoline derivatives

Sergio Mantegani, Enzo Brambilla, Carla Caccia, Gabriele Damiani, Maria Gioia Fornaretto, Robert A. McArthur, Mario Varasi

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Novel classes of 13- and 14-tertbutyl-ergoline derivatives were prepared, and characterised in vitro for their affinity for adrenergic, dopaminergic and serotonergic binding sites. This study particularly examines the importance of the presence and the position of the tert-butyl group in conferring either significant 5-HT(1A) or 5-HT₂ affinity and selectivity respectively.

Original language	English
Pages (from-to)	1117-1122
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	9
DOIs	https://doi.org/10.1016/S0960-894X(98)00166-8
Publication status	Published - May 1998

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Organic Chemistry
Drug Discovery
Pharmaceutical Science

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title = "Serotonergic ergoline derivatives",

abstract = "Novel classes of 13- and 14-tertbutyl-ergoline derivatives were prepared, and characterised in vitro for their affinity for adrenergic, dopaminergic and serotonergic binding sites. This study particularly examines the importance of the presence and the position of the tert-butyl group in conferring either significant 5-HT(1A) or 5-HT2 affinity and selectivity respectively.",

author = "Sergio Mantegani and Enzo Brambilla and Carla Caccia and Gabriele Damiani and Fornaretto, {Maria Gioia} and McArthur, {Robert A.} and Mario Varasi",

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AU - Mantegani, Sergio

AU - Brambilla, Enzo

AU - Caccia, Carla

AU - Damiani, Gabriele

AU - Fornaretto, Maria Gioia

AU - McArthur, Robert A.

AU - Varasi, Mario

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AB - Novel classes of 13- and 14-tertbutyl-ergoline derivatives were prepared, and characterised in vitro for their affinity for adrenergic, dopaminergic and serotonergic binding sites. This study particularly examines the importance of the presence and the position of the tert-butyl group in conferring either significant 5-HT(1A) or 5-HT2 affinity and selectivity respectively.

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