Serotonergic influence on cholinergic-induced analgesia: differences in two inbred strains of mice

Flaminia Pavone, Sandro Fagioli

Research output: Contribution to journalArticle

Abstract

C57BL/6 (C57) and DBA/2 (DBA) inbred mice showed different analgesic responses to cholinergic stimulation. The simultaneous administration of muscarinic and serotonergic agonists, oxotremorine and 5-methoxy-NN-dimethyltryptamine (5-MeODMT), lowered the antinociceptive effect of the cholinergic drug in DBA mice, while no effects were detectable in the C57 strain. These results suggest a strain-dependent behavioural effect of the interaction of cholinergic and serotonergic neuronal systems.

Original languageEnglish
Pages (from-to)347-350
Number of pages4
JournalBrain Research
Volume577
Issue number2
DOIs
Publication statusPublished - Apr 17 1992

Keywords

  • Genetic difference
  • Mouse
  • Nociception
  • Oxotremorine
  • Serotonergic drug

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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