Serotonin-2C and serotonin-1A receptor genes are not associated with psychotic symptomatology of mood disorders

Alessandro Serretti, Roberta Lilli, Cristina Lorenzi, Enrico Lattuada, Enrico Smeraldi

Research output: Contribution to journalArticlepeer-review


The serotonergic system is involved in both pathophysiology and treatment of mood disorders. In the present study we investigated the possible influence of the polymorphisms of the serotonin-1A and 2C receptor genes on the symptomatology of mood disorders. Eighty-four inpatients affected by mood disorders (72 bipolar and 12 major depressive disorder) were assessed by the Operational Criteria Checklist for Psychotic Illness to score their lifetime psychotic symptomatology. The subjects were also typed for 5HT1A and 5HT2C variants using polymerase chain reaction techniques. No association was found between 5HT2C and psychopathology as defined by the four symptomatologic factors used as phenotype definition (mania, depression, delusion, and disorganization) even when bipolar subjects were analyzed separately. Only one subject with the 5HT1A variant was observed. Genetic variation at the 5HT1A and 5HT2C receptor genes does not, therefore, play a major role in the pathogenesis of mood disorders symptomatology. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)161-166
Number of pages6
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Issue number2
Publication statusPublished - Apr 3 2000


  • Bipolar disorder
  • Depressive disorder
  • Phenotype
  • Serotonin
  • Serotonin receptors

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)


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