Serotonin and norepinephrine reuptake inhibitors antidepressant use is related to lower baroreflex sensitivity independently of the severity of depressive symptoms. A community-study of 9213 participants from the Paris Prospective Study III

Jean Philippe Empana, Christof Prugger, Frédérique Thomas, Marie Cécile Perier, Luca Zanoli, Paolo Castiglioni, Catherine Guibout, Sophie Causeret, Caroline Barnes, Cédric Lemogne, Gianfranco Parati, Stéphane Laurent, Bruno M. Pannier, Pierre Boutouyrie, Xavier Jouven

Research output: Contribution to journalArticle

Abstract

Background and aims: We assess the respective relationship of high depressive symptoms and antidepressant use (ATD) with baroreflex sensitivity (BRS) in subjects from the community who enrolled the Paris Prospective Study III. Methods: Recruitment took place in a large health preventive centre in Paris (France), between May 2008 and June 2012. BRS was investigated by spectral analysis of the spontaneous carotid distension rate and RR intervals using non-invasive high-resolution ultrasound carotid-echotracking. A total score ≥7 on a 13-item standardized questionnaire defined the presence of high depressive symptoms. Information on ATD use was obtained on a face-to-face interview with a medical doctor who checked the most recent medical prescriptions and/or medical package. Results: There were 9213 participants aged 50-75 years (38.6% of women), including 5.6% with high-depressive symptoms and 5.2% on ATD. High depressive symptoms were not associated with low BRS (below the median) even in unadjusted logistic regression analysis (OR = 1.09; 95%CI: 0.91-1.30). Instead, ATD use was related to low BRS in multivariate logistic regression analysis (OR = 1.27; 95% CI: 1.04-1.54). This association remains after adjusting for and matching on propensity score of receiving ATD. A specific association with serotonin and norepinephrine reuptake inhibitors was observed (OR = 1.94; 95% CI: 1.16-3.22). Conclusions: ATD use and serotonin and norepinephrine reuptake inhibitors in particular, but not high depressive symptoms, is associated with low BRS. If confirmed, these results may bring novel insights into the mechanisms linking depressive symptoms and/or ATD use with cardiovascular disease onset.

Original languageEnglish
Pages (from-to)55-62
Number of pages8
JournalAtherosclerosis
Volume251
DOIs
Publication statusPublished - Aug 1 2016

Keywords

  • Antidepressants
  • Baroreflex sensitivity
  • Depressive disorders
  • Echotracking
  • Epidemiology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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