Serotonin inhibition of the NMDA receptor/nitric oxide/cyclic GMP pathway in rat cerebellum: Involvement of 5-hydroxytryptamine(2C) receptors

Manuela Marcoli, Guido Maura, Massimo Tortarolo, Maurizio Raiteri

Research output: Contribution to journalArticle

Abstract

Previous studies have shown that 5-hydroxytryptamine (5-HT) can potently inhibit glutamatergic transmission in rat cerebellum through the activation of multiple 5-HT receptors. The aim of this study was to subclassify the 5- HT2 receptor mediating inhibition of the cyclic GMP response elicited by N- methyl-D-aspartate in adult rat cerebellar slices. Seven receptor antagonists, endowed with relative selectivities for the 5-HT(2A), 5-HT(2B), and 5-HT(2C) subtypes, differentially affected the inhibition by (±)-1- (2,5-dimethoxy-4-iodophenyl)-2-aminopropane of the cyclic GMP response, suggesting that the receptor involved belongs to the 5-HT(2C) subtype.

Original languageEnglish
Pages (from-to)427-430
Number of pages4
JournalJournal of Neurochemistry
Volume69
Issue number1
Publication statusPublished - Jul 1997

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Keywords

  • 5-Hydroxytryptamine (2C) receptors
  • 5-Hydroxytryptamine receptor subtypes
  • Cerebellum
  • Cyclic GMP
  • Glutamate interaction
  • Nitric oxide
  • NMDA receptors
  • Serotonin

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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