Serotonin inhibits induction of long-term potentiation at commissural synapses in hippocampus

Flavio Villani, Daniel Johnston

Research output: Contribution to journalArticle

Abstract

This study tests the effect of serotonin (5-HT) (1 μM) on the induction of long-term potentiation (LTP) at the commissural/associational (C/A)-CA3 synapse. The C/A input to CA3 was measured by field potentials in rat hippocampal slices. At the concentrations used 5-HT had little or no effect on synaptic transmission, but suppressed the induction of LTP. Similar results were observed in normal saline and in saline containing picrotoxin (10 μM) and bicuculline (10 μM) to block GABAA inhibition. Perfusion with methylsergide (1 μM), a 5-HT antagonist, had no effect on synaptic transmission, but partially blocked the effect of 5-HT on LTP. The block of LTP by 5-HT could be overcome by using a higher intensity of stimulation suggesting that 5-HT might hyperpolarize the postsynaptic neurons to inhibit LTP induction. We conclude that the activation of serotonergic receptors inhibits the induction of LTP at the C/A-CA3 synapse.

Original languageEnglish
Pages (from-to)304-308
Number of pages5
JournalBrain Research
Volume606
Issue number2
DOIs
Publication statusPublished - Mar 26 1993

Keywords

  • Hippocampus
  • Long-term potentiation
  • Neuromodulation
  • Plasticity
  • Serotonin
  • Synaptic transmission

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Serotonin inhibits induction of long-term potentiation at commissural synapses in hippocampus'. Together they form a unique fingerprint.

  • Cite this