Serotonin levels and turnover in different brain areas of isolated aggressive or non-aggressive strains of mice

Eliane Kempf, Stefano Puglisi-Allegra, Simona Cabib, Carmen Schleef, Paul Mandel

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

1. After eight weeks of individual housing DBA/2 but not C57 Bl/6 (C57) mice showed high levels of aggressive responses in comparison with grouped mice. 2. Social isolation did not modify serotonin (5-HT) levels in either strain of mice, while it produced a decrease of turnover rate in amygdala, lateral hypothalamus and pons in C57 mice and in lateral hypothalamus and pons of DBA mice. 3. When isolated mice of both C57 and DBA strains are compared, no differences in turnover rate in amygdala and pons are evident, while isolated DBA mice show significant lower turnover values in lateral hypothalamus in comparison with isolated C57 mice. 4. A possible suggestion emerging from our results is that aggressive responses exhibited by isolated DBA mice but not by isolated C57 mice may be related to lower 5-HT turnover rate in lateral hypothalamus.

Original languageEnglish
Pages (from-to)365-371
Number of pages7
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume8
Issue number3
Publication statusPublished - 1984

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Serotonin
Lateral Hypothalamic Area
Brain
Inbred DBA Mouse
Pons
Amygdala
Social Isolation

Keywords

  • aggressive behavior
  • brain
  • brain serotonin levels
  • isolation
  • mice
  • serotonin turnover

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

Cite this

Serotonin levels and turnover in different brain areas of isolated aggressive or non-aggressive strains of mice. / Kempf, Eliane; Puglisi-Allegra, Stefano; Cabib, Simona; Schleef, Carmen; Mandel, Paul.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 8, No. 3, 1984, p. 365-371.

Research output: Contribution to journalArticle

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