Abstract
Objectives: Serotonin-producing tumors of the pancreas are rare endocrine neoplasms composed of enterochromaffin (EC) cells that have been mainly described in the literature as case reports. This study analyzes the clinicopathologic features of a series of pancreatic EC cell neoplasms and their similarities to and differences from intestinal EC cell tumors. Methods: The morphological, immunohistochemical, ultrastructural, and fluorescent in situ hybridization features of 15 pancreatic and 20 intestinal serotonin-producing neoplasms were compared. In addition, we reviewed the literature on pancreatic serotonin-producing tumors to better understand the clinicopathologic features of this rare tumor type. Results: The lack of substance P and acidic fibroblast growth factor immunoreactivity; the low immunohistochemical expression of CDX2, vesicular monoamine transporter 1, connective tissue growth factor, and prostatic acid phosphatase; the lack of S100-positive sustentacular cells; the strong expression of vesicular monoamine transporter 2; and peculiar ultrastructural features characterize pancreatic EC cell tumors and differentiate them from intestinal ones, although both categories show similar chromosome 18 cytogenetic alterations. The review of the literature indicates that pancreatic functioning tumors associated with the carcinoid syndrome arise in younger patients and are larger, more frequently malignant, and more aggressive neoplasms than pancreatic nonfunctioning ones. Conclusions: Pancreatic EC cell tumors show several different morphological features compared with related intestinal tumors despite similar cytogenetic alterations on chromosome 18.
| Original language | English |
|---|---|
| Pages (from-to) | 883-895 |
| Number of pages | 13 |
| Journal | Pancreas |
| Volume | 40 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Aug 2011 |
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Keywords
- carcinoid
- EC cell
- endocrine tumor
- pancreas
- serotonin
ASJC Scopus subject areas
- Hepatology
- Internal Medicine
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Serotonin-producing enterochromaffin cell tumors of the pancreas : Clinicopathologic study of 15 cases and comparison with intestinal enterochromaffin cell tumors. / La Rosa, Stefano; Franzi, Francesca; Albarello, Luca; Schmitt, Anja; Bernasconi, Barbara; Tibiletti, Maria Grazia; Finzi, Giovanna; Placidi, Claudia; Perren, Aurel; Capella, Carlo.
In: Pancreas, Vol. 40, No. 6, 08.2011, p. 883-895.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serotonin-producing enterochromaffin cell tumors of the pancreas
T2 - Clinicopathologic study of 15 cases and comparison with intestinal enterochromaffin cell tumors
AU - La Rosa, Stefano
AU - Franzi, Francesca
AU - Albarello, Luca
AU - Schmitt, Anja
AU - Bernasconi, Barbara
AU - Tibiletti, Maria Grazia
AU - Finzi, Giovanna
AU - Placidi, Claudia
AU - Perren, Aurel
AU - Capella, Carlo
PY - 2011/8
Y1 - 2011/8
N2 - Objectives: Serotonin-producing tumors of the pancreas are rare endocrine neoplasms composed of enterochromaffin (EC) cells that have been mainly described in the literature as case reports. This study analyzes the clinicopathologic features of a series of pancreatic EC cell neoplasms and their similarities to and differences from intestinal EC cell tumors. Methods: The morphological, immunohistochemical, ultrastructural, and fluorescent in situ hybridization features of 15 pancreatic and 20 intestinal serotonin-producing neoplasms were compared. In addition, we reviewed the literature on pancreatic serotonin-producing tumors to better understand the clinicopathologic features of this rare tumor type. Results: The lack of substance P and acidic fibroblast growth factor immunoreactivity; the low immunohistochemical expression of CDX2, vesicular monoamine transporter 1, connective tissue growth factor, and prostatic acid phosphatase; the lack of S100-positive sustentacular cells; the strong expression of vesicular monoamine transporter 2; and peculiar ultrastructural features characterize pancreatic EC cell tumors and differentiate them from intestinal ones, although both categories show similar chromosome 18 cytogenetic alterations. The review of the literature indicates that pancreatic functioning tumors associated with the carcinoid syndrome arise in younger patients and are larger, more frequently malignant, and more aggressive neoplasms than pancreatic nonfunctioning ones. Conclusions: Pancreatic EC cell tumors show several different morphological features compared with related intestinal tumors despite similar cytogenetic alterations on chromosome 18.
AB - Objectives: Serotonin-producing tumors of the pancreas are rare endocrine neoplasms composed of enterochromaffin (EC) cells that have been mainly described in the literature as case reports. This study analyzes the clinicopathologic features of a series of pancreatic EC cell neoplasms and their similarities to and differences from intestinal EC cell tumors. Methods: The morphological, immunohistochemical, ultrastructural, and fluorescent in situ hybridization features of 15 pancreatic and 20 intestinal serotonin-producing neoplasms were compared. In addition, we reviewed the literature on pancreatic serotonin-producing tumors to better understand the clinicopathologic features of this rare tumor type. Results: The lack of substance P and acidic fibroblast growth factor immunoreactivity; the low immunohistochemical expression of CDX2, vesicular monoamine transporter 1, connective tissue growth factor, and prostatic acid phosphatase; the lack of S100-positive sustentacular cells; the strong expression of vesicular monoamine transporter 2; and peculiar ultrastructural features characterize pancreatic EC cell tumors and differentiate them from intestinal ones, although both categories show similar chromosome 18 cytogenetic alterations. The review of the literature indicates that pancreatic functioning tumors associated with the carcinoid syndrome arise in younger patients and are larger, more frequently malignant, and more aggressive neoplasms than pancreatic nonfunctioning ones. Conclusions: Pancreatic EC cell tumors show several different morphological features compared with related intestinal tumors despite similar cytogenetic alterations on chromosome 18.
KW - carcinoid
KW - EC cell
KW - endocrine tumor
KW - pancreas
KW - serotonin
UR - http://www.scopus.com/inward/record.url?scp=80051550986&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80051550986&partnerID=8YFLogxK
U2 - 10.1097/MPA.0b013e31822041a9
DO - 10.1097/MPA.0b013e31822041a9
M3 - Article
C2 - 21705949
AN - SCOPUS:80051550986
VL - 40
SP - 883
EP - 895
JO - Pancreas
JF - Pancreas
SN - 0885-3177
IS - 6
ER -