Serotonin receptor 2A, 2C, 1A genes and response to lithium prophylaxis in mood disorders

Alessandro Serretti, Cristina Lorenzi, Roberta Lilli, Enrico Smeraldi

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The aim of this study was to investigate the influence of serotonin receptors 2A, 2C and 1A gene variants on lithium prophylactic efficacy in mood disorders. One hundred and twenty-four subjects affected by bipolar (n=102) and major depressive (n=22) disorder were followed prospectively for an average of 52 months and were typed for 5-HT2A (T102C: n=111, HTP: n=104), 5-HT2C (n=110) and 5-HT1A (n=61) variants. Both 5-HT2A and 5-HT2C variants were not associated with lithium outcome. Consideration of possible stratification effects like gender, polarity, family history, age at onset and duration of lithium treatment did not influence results. No 5-HT1A gene variant was identified. 5-HT2A and 2C variants are not, therefore, associated with lithium prophylactic efficacy in mood disorders. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)89-98
Number of pages10
JournalJournal of Psychiatric Research
Volume34
Issue number2
DOIs
Publication statusPublished - Mar 1 2000

Fingerprint

Receptor, Serotonin, 5-HT2C
Receptor, Serotonin, 5-HT2A
Mood Disorders
Lithium
Genes
Receptor, Serotonin, 5-HT1A
Age of Onset

Keywords

  • Bipolar disorder
  • Follow-up studies
  • Lithium
  • Serotonin receptors
  • Treatment outcome

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Serotonin receptor 2A, 2C, 1A genes and response to lithium prophylaxis in mood disorders. / Serretti, Alessandro; Lorenzi, Cristina; Lilli, Roberta; Smeraldi, Enrico.

In: Journal of Psychiatric Research, Vol. 34, No. 2, 01.03.2000, p. 89-98.

Research output: Contribution to journalArticle

Serretti, Alessandro ; Lorenzi, Cristina ; Lilli, Roberta ; Smeraldi, Enrico. / Serotonin receptor 2A, 2C, 1A genes and response to lithium prophylaxis in mood disorders. In: Journal of Psychiatric Research. 2000 ; Vol. 34, No. 2. pp. 89-98.
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