Sindrome serotoninergica: Perché anche il cardiologo la dovrebbe conoscere (e temere)

Translated title of the contribution: Serotonin syndrome: Why even the cardiologist should know (and fear)

Pier Luigi Temporelli, Alessandro Boccanelli, Giovambattista Desideri, Pompilio Faggiano, Gabriele Mora, Fabrizio Oliva, Pierfranco Terrosu

Research output: Contribution to journalArticlepeer-review


The serotonin syndrome (SS) represents a life-threatening adverse drug reaction, caused by serotonin overload in the central and peripheral nervous system, producing autonomic instability, neuromuscular and cardiovascular abnormalities, and cognitive alterations. The incidence of SS has been growing over the last few years, as a consequence of population aging and the steadily increasing use of pro-serotoninergic agents in clinical practice, in the presence of various comorbidities, mainly cardiovascular. Cardiologists often use combination therapies including serotoninergic agents, and should therefore consider the risk of serotoninergic adverse events caused by inappropriate drug interactions. SS is often difficult to diagnose and may be life-threatening if not adequately managed. Considering the several published case reports of overdose or not recommended associations, a greater awareness by clinicians about the potential risks associated with inappropriate use of these drugs is needed, as well as better information on the clinical features and therapeutic approaches to SS.

Translated title of the contributionSerotonin syndrome: Why even the cardiologist should know (and fear)
Original languageItalian
Pages (from-to)34-43
Number of pages10
JournalGiornale Italiano di Cardiologia
Issue number1
Publication statusPublished - Jan 1 2015

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)


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