Serotonin transporter gene (5-HTTLPR) is not associated with depressive symptomatology in mood disorders

A. Serretti, C. Cusin, E. Lattuada, D. Di Bella, M. Catalano, E. Smeraldi

Research output: Contribution to journalArticlepeer-review

Abstract

Disturbances of the serotoninergic neutrotransmitter system have been implicated in the pathogenesis of mood disorders. A functional polymorphism in the upstream regulatory region of the serotonin transporter gene (5-HTTLPR) has been recently reported to be associated with both unipolar and bipolar disorder. In this study, we investigated the possibility that the 5-HTTLPR might be associated with depressive symptomatology in a sample of mood disorder subjects. One hundred and thirty-two psychiatric inpatients affected by major depressive (n = 67) and bipolar (n = 65) disorder (DSM-IV) were assessed at admission by the Hamilton Depression Rating Scale (HAMD-21, divided into Core, Sleep, Activity, Psychic anxiety, Somatic anxiety and Delusion clusters) and were typed using PCR techniques. The only prior treatment permitted was low dose benzodiazepines (<5 mg diazepam or equivalent); no prior (<2 weeks) antidepressant or neuroleptic treatment was allowed. 5-HTTLPR variants were not associated with total depressive symptomatology as measured by HAMD. The short 5-HTTLPR variant was marginally associated with higher psychic anxiety scores (F = 7.11, d.f. = 1262, P = 0.008). The association was stronger among bipolars and early onset subjects. 5-HTTLPR variants were not associated with the remaining symptom clusters. The upstream regulatory region of the serotonin transporter gene has not, therefore, a major influence on the depressive symptomatology in mood disorder subjects.

Original languageEnglish
Pages (from-to)280-283
Number of pages4
JournalMolecular Psychiatry
Volume4
Issue number3
Publication statusPublished - 1999

Keywords

  • Anxiety
  • Bipolar disorder
  • Depressive disorder
  • Phenotype
  • Polymorphism
  • Serotonin

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health

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