Serotonin transporter gene is not associated with symptomatology of schizophrenia

Alessandro Serretti, Marco Catalano, Enrico Smeraldi

Research output: Contribution to journalArticlepeer-review


The serotonin transporter gene is a primary candidate for involvement in major psychoses. A functional polymorphism in the upstream regulatory region of the serotonin transporter gene (5-HTTLPR) has recently been reported to be associated with a variety of psychopathological conditions. In the present study, we investigated the potential influence of the 5-HTTLPR on the psychopathology of schizophrenia. One hundred and sixty-one inpatients affected by schizophrenia (DSMIII-R) were assessed by the Operational Criteria checklist for psychotic illness (OPCRIT) and were typed for their 5- HTTLPR variants by PCR techniques. Mania, Depression, Delusion and Disorganization were the four symptomatologic factors used to define phenotype. 5-HTTLPR variants were not associated with these symptomatologic factors, and consideration of possible stratification effects such as sex, and age of onset did not reveal any association either. The serotonin transporter gene is not a liability factor for the symptomatology of schizophrenia.

Original languageEnglish
Pages (from-to)33-39
Number of pages7
JournalSchizophrenia Research
Issue number1
Publication statusPublished - Jan 4 1999


  • Phenotype
  • Schizophrenia
  • Serotonin
  • Serotonin receptors

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)


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