Serotonin transporter gene polymorphic element 5-HTTLPR increases the risk of sporadic parkinson's disease in Italy

Diego Albani, Angelica Vittori, Sara Batelli, Letizia Polito, Stefania De Mauro, Daniela Galimberti, Elio Scarpini, Carlo Lovati, Claudio Mariani, Gianluigi Forloni

Research output: Contribution to journalArticlepeer-review

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder causing muscular rigidity, resting tremor and bradykinesia. We conducted an association study assessing how PD risk in Italy was influenced by the serotonin transporter gene (SLC6A4) polymorphic region 5-HTTLPR, consisting of an insertion/deletion (long allele-L/short allele-S) of 43 bp in the SLC6A4 promoter region. The SLC6A4 promoter single nucleotide polymorphism rs25531(A→G) was evaluated too. We collected 837 independent subjects (393 PD, 444 controls). An association between the 5-HTTLPR polymorphism and risk of PD (S/S genotype OR [95% CI]: 1.7[1.2-2.5], p = 0.002) was found. The rs25531 and the haplotype 5-HTTLPR/rs25531 did not associate with risk of PD. Our data indicate that the 5-HTTLPR polymorphic element within the SLC6A4 promoter may govern the genetic risk of PD in Italians.

Original languageEnglish
Pages (from-to)120-123
Number of pages4
JournalEuropean Neurology
Volume62
Issue number2
DOIs
Publication statusPublished - Jul 2009

Keywords

  • 5-HTTLPR
  • Genetics
  • Parkinson's disease
  • Rs25531
  • Serotonin transporter

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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