Abstract
We tested the hypothesis that allelic variation of 5-HTT linked polymorphic region (5-HTTLPR) could influence illness onset and recurrence in 129 bipolar and 128 unipolar recurrent patients. Among bipolar patients, homozygotes for the short variant showed an earlier age at onset and a lower recurrence rate than heterozygotes and homozygotes for the long variant. Unipolar patients showed a trend toward the same difference. Data support a role for 5-HTTLPR in course of affective illness.
| Original language | English |
|---|---|
| Pages (from-to) | 73-75 |
| Number of pages | 3 |
| Journal | European Neuropsychopharmacology |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- 5-HTTLPR
- Antidepressant response
- Bipolar
- Depression
- Functional polymorphism
- Illness onset and recurrence
- Unipolar
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Biological Psychiatry
- Neurology
- Pharmacology
- Psychology(all)
Cite this
Serotonin transporter promoter genotype and illness recurrence in mood disorders. / Smeraldi, Enrico; Benedetti, Francesco; Zanardi, Raffaella.
In: European Neuropsychopharmacology, Vol. 12, No. 1, 2002, p. 73-75.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serotonin transporter promoter genotype and illness recurrence in mood disorders
AU - Smeraldi, Enrico
AU - Benedetti, Francesco
AU - Zanardi, Raffaella
PY - 2002
Y1 - 2002
N2 - We tested the hypothesis that allelic variation of 5-HTT linked polymorphic region (5-HTTLPR) could influence illness onset and recurrence in 129 bipolar and 128 unipolar recurrent patients. Among bipolar patients, homozygotes for the short variant showed an earlier age at onset and a lower recurrence rate than heterozygotes and homozygotes for the long variant. Unipolar patients showed a trend toward the same difference. Data support a role for 5-HTTLPR in course of affective illness.
AB - We tested the hypothesis that allelic variation of 5-HTT linked polymorphic region (5-HTTLPR) could influence illness onset and recurrence in 129 bipolar and 128 unipolar recurrent patients. Among bipolar patients, homozygotes for the short variant showed an earlier age at onset and a lower recurrence rate than heterozygotes and homozygotes for the long variant. Unipolar patients showed a trend toward the same difference. Data support a role for 5-HTTLPR in course of affective illness.
KW - 5-HTTLPR
KW - Antidepressant response
KW - Bipolar
KW - Depression
KW - Functional polymorphism
KW - Illness onset and recurrence
KW - Unipolar
UR - http://www.scopus.com/inward/record.url?scp=0036154267&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036154267&partnerID=8YFLogxK
U2 - 10.1016/S0924-977X(01)00142-0
DO - 10.1016/S0924-977X(01)00142-0
M3 - Article
C2 - 11788243
AN - SCOPUS:0036154267
VL - 12
SP - 73
EP - 75
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
SN - 0924-977X
IS - 1
ER -