Abstract
We tested the hypothesis that allelic variation of 5-HTT linked polymorphic region (5-HTTLPR) could influence illness onset and recurrence in 129 bipolar and 128 unipolar recurrent patients. Among bipolar patients, homozygotes for the short variant showed an earlier age at onset and a lower recurrence rate than heterozygotes and homozygotes for the long variant. Unipolar patients showed a trend toward the same difference. Data support a role for 5-HTTLPR in course of affective illness.
Original language | English |
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Pages (from-to) | 73-75 |
Number of pages | 3 |
Journal | European Neuropsychopharmacology |
Volume | 12 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2002 |
Keywords
- 5-HTTLPR
- Antidepressant response
- Bipolar
- Depression
- Functional polymorphism
- Illness onset and recurrence
- Unipolar
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Biological Psychiatry
- Neurology
- Pharmacology
- Psychology(all)