Serotonin transporter promoter genotype and illness recurrence in mood disorders

Enrico Smeraldi, Francesco Benedetti, Raffaella Zanardi

Research output: Contribution to journalArticlepeer-review


We tested the hypothesis that allelic variation of 5-HTT linked polymorphic region (5-HTTLPR) could influence illness onset and recurrence in 129 bipolar and 128 unipolar recurrent patients. Among bipolar patients, homozygotes for the short variant showed an earlier age at onset and a lower recurrence rate than heterozygotes and homozygotes for the long variant. Unipolar patients showed a trend toward the same difference. Data support a role for 5-HTTLPR in course of affective illness.

Original languageEnglish
Pages (from-to)73-75
Number of pages3
JournalEuropean Neuropsychopharmacology
Issue number1
Publication statusPublished - 2002


  • 5-HTTLPR
  • Antidepressant response
  • Bipolar
  • Depression
  • Functional polymorphism
  • Illness onset and recurrence
  • Unipolar

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neurology
  • Pharmacology
  • Psychology(all)


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