Serotonin transporter promoter genotype and illness recurrence in mood disorders

Enrico Smeraldi; Francesco Benedetti; Raffaella Zanardi

doi:10.1016/S0924-977X(01)00142-0

Serotonin transporter promoter genotype and illness recurrence in mood disorders

Enrico Smeraldi, Francesco Benedetti, Raffaella Zanardi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

We tested the hypothesis that allelic variation of 5-HTT linked polymorphic region (5-HTTLPR) could influence illness onset and recurrence in 129 bipolar and 128 unipolar recurrent patients. Among bipolar patients, homozygotes for the short variant showed an earlier age at onset and a lower recurrence rate than heterozygotes and homozygotes for the long variant. Unipolar patients showed a trend toward the same difference. Data support a role for 5-HTTLPR in course of affective illness.

Original language	English
Pages (from-to)	73-75
Number of pages	3
Journal	European Neuropsychopharmacology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/S0924-977X(01)00142-0
Publication status	Published - 2002

Keywords

5-HTTLPR
Antidepressant response
Bipolar
Depression
Functional polymorphism
Illness onset and recurrence
Unipolar

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry
Neurology
Pharmacology
Psychology(all)

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10.1016/S0924-977X(01)00142-0

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title = "Serotonin transporter promoter genotype and illness recurrence in mood disorders",

abstract = "We tested the hypothesis that allelic variation of 5-HTT linked polymorphic region (5-HTTLPR) could influence illness onset and recurrence in 129 bipolar and 128 unipolar recurrent patients. Among bipolar patients, homozygotes for the short variant showed an earlier age at onset and a lower recurrence rate than heterozygotes and homozygotes for the long variant. Unipolar patients showed a trend toward the same difference. Data support a role for 5-HTTLPR in course of affective illness.",

keywords = "5-HTTLPR, Antidepressant response, Bipolar, Depression, Functional polymorphism, Illness onset and recurrence, Unipolar",

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AU - Benedetti, Francesco

AU - Zanardi, Raffaella

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AB - We tested the hypothesis that allelic variation of 5-HTT linked polymorphic region (5-HTTLPR) could influence illness onset and recurrence in 129 bipolar and 128 unipolar recurrent patients. Among bipolar patients, homozygotes for the short variant showed an earlier age at onset and a lower recurrence rate than heterozygotes and homozygotes for the long variant. Unipolar patients showed a trend toward the same difference. Data support a role for 5-HTTLPR in course of affective illness.

KW - 5-HTTLPR

KW - Antidepressant response

KW - Bipolar

KW - Depression

KW - Functional polymorphism

KW - Illness onset and recurrence

KW - Unipolar

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Serotonin transporter promoter genotype and illness recurrence in mood disorders

Abstract

Keywords

ASJC Scopus subject areas

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