Studio del trasporto di serotonina nelle piastrine di pazienti in eta evolutiva con disturbi psicopatologici

Translated title of the contribution: Serotonin uptake in platelets from child neuropsychiatric patients

B. Begni, M. Molteni, M. Nobile, A. Frigerio, C. Ferrarese

Research output: Contribution to journalArticlepeer-review


Serotonin uptake abnormalities have been widely described in depressed adult patients. However, few studies analyzed this peripheral marker of serotonergic system in child neuropsychiatric disorders, despite the clinical use of serotonin uptake inhibitors in these syndromes. In this preliminary study, we investigated possible modifications of serotonin uptake in platelets from 34 child neuropsychiatric patients, aged 7-16, devided, according to the ICD10 classification, into the following cathegories: Attention Deficit Hyperactivity Disorder (ADHD), child autism, anxious syndromes, dysthymia. 10 normal age and sex related children were used as controls. Serotonin uptake was determined in fresh platelet preparations, using [3H]serotonin, according to the method of Arora and Meltzer. Platelet serotonin uptake was decreased by 60% (p

Translated title of the contributionSerotonin uptake in platelets from child neuropsychiatric patients
Original languageItalian
Pages (from-to)13-19
Number of pages7
JournalSAGGI - Neuropsicologia Infantile Psicopedagogia Riabilitazione
Issue number1
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neuroscience(all)
  • Psychology(all)


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