Abstract
Structure-activity relationships in a series of dihydrobenzofuran derivatives related structurally to the 5-HT3 antagonist and 5-HT4 agonist ADR 932 (1) were investigated. Members of this series, such as (18) and (23), were found to be 5-HT4 agonists or partial agonists endowed with remarkably high affinity and selectivity.
Original language | English |
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Pages (from-to) | 263-266 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 6 |
Issue number | 3 |
Publication status | Published - 1996 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science