Serotoninergic 5-HT3 and 5-HT4 receptor activities of dihydrobenzofuran carboxylic acid derivatives

D. Fancelli; C. Caccia; M. G. Fornaretto; R. McArthur; D. Severino; F. Vaghi; M. Varasi

Serotoninergic 5-HT3 and 5-HT4 receptor activities of dihydrobenzofuran carboxylic acid derivatives

D. Fancelli, C. Caccia, M. G. Fornaretto, R. McArthur, D. Severino, F. Vaghi, M. Varasi

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Structure-activity relationships in a series of dihydrobenzofuran derivatives related structurally to the 5-HT₃ antagonist and 5-HT₄ agonist ADR 932 (1) were investigated. Members of this series, such as (18) and (23), were found to be 5-HT₄ agonists or partial agonists endowed with remarkably high affinity and selectivity.

Original language	English
Pages (from-to)	263-266
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	6
Issue number	3
Publication status	Published - 1996

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Organic Chemistry
Drug Discovery
Pharmaceutical Science

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abstract = "Structure-activity relationships in a series of dihydrobenzofuran derivatives related structurally to the 5-HT3 antagonist and 5-HT4 agonist ADR 932 (1) were investigated. Members of this series, such as (18) and (23), were found to be 5-HT4 agonists or partial agonists endowed with remarkably high affinity and selectivity.",

author = "D. Fancelli and C. Caccia and Fornaretto, {M. G.} and R. McArthur and D. Severino and F. Vaghi and M. Varasi",

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AU - McArthur, R.

AU - Severino, D.

AU - Vaghi, F.

AU - Varasi, M.

PY - 1996

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AB - Structure-activity relationships in a series of dihydrobenzofuran derivatives related structurally to the 5-HT3 antagonist and 5-HT4 agonist ADR 932 (1) were investigated. Members of this series, such as (18) and (23), were found to be 5-HT4 agonists or partial agonists endowed with remarkably high affinity and selectivity.

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