Serotoninergic and dopaminergic modulation of cortico-striatal circuit in executive and attention deficits induced by NMDA receptor hypofunction in the 5-choice serial reaction time task

Mirjana Carli, Roberto W. Invernizzi

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Executive functions are an emerging propriety of neuronal processing in circuits encompassing frontal cortex and other cortical and subcortical brain regions such as basal ganglia and thalamus. Glutamate serves as the major neurotrasmitter in these circuits where glutamate receptors of NMDA type play key role. Serotonin and dopamine afferents are in position to modulate intrinsic glutamate neurotransmission along these circuits and in turn to optimize circuit performance for specific aspects of executive control over behavior. In this review, we focus on the 5-choice serial reaction time task which is able to provide various measures of attention and executive control over performance in rodents and the ability of prefrontocortical and striatal serotonin 5-HT1A, 5-HT2A, and 5-HT2C as well as dopamine D1-and D2-like receptors to modulate different aspects of executive and attention disturbances induced by NMDA receptor hypofunction in the prefrontal cortex. These behavioral studies are integrated with findings from microdialysis studies. These studies illustrate the control of attention selectivity by serotonin 5-HT1A, 5-HT2A, 5-HT2C, and dopamine D1- but not D2-like receptors and a distinct contribution of these cortical and striatal serotonin and dopamine receptors to the control of different aspects of executive control over performance such as impulsivity and compulsivity. An association between NMDA antagonist-induced increase in glutamate release in the prefrontal cortex and attention is suggested. Collectively, this review highlights the functional interaction of serotonin and dopamine with NMDA dependent glutamate neurotransmission in the cortico-striatal circuitry for specific cognitive demands and may shed some light on how dysregulation of neuronal processing in these circuits may be implicated in specific neuropsychiatric disorders.

Original languageEnglish
Article number58
JournalFrontiers in Neural Circuits
Volume8
Issue numberJUNE
DOIs
Publication statusPublished - Jun 11 2014

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Corpus Striatum
Executive Function
N-Methyl-D-Aspartate Receptors
Reaction Time
Glutamic Acid
Dopamine
Serotonin
N-Methylaspartate
Prefrontal Cortex
Synaptic Transmission
Aptitude
Impulsive Behavior
Serotonin Receptors
Microdialysis
Dopamine Receptors
Glutamate Receptors
Frontal Lobe
Basal Ganglia
Thalamus
Rodentia

Keywords

  • 5-HT receptors
  • Attention
  • DA receptors
  • Dorsal striatum
  • Executive functions
  • GLU release
  • NMDA receptor
  • PFC

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Cellular and Molecular Neuroscience
  • Sensory Systems
  • Cognitive Neuroscience

Cite this

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