Serotype Distribution of Streptococcus pneumoniae causing Invasive Pneumococcal Disease at Bambino Gesù Children's Hospital in Rome: Is It Time for a New Vaccine?

Luciana Nicolosi; Elena Bozzola; Andrzej Krzysztofiak; Annausa Pantosti; Laura Lancella; Paola Bernaschi; Maria Rosaria Marchili; Alberto Villani

doi:10.1055/s-0037-1615784

Serotype Distribution of Streptococcus pneumoniae causing Invasive Pneumococcal Disease at Bambino Gesù Children's Hospital in Rome: Is It Time for a New Vaccine?

Luciana Nicolosi, Elena Bozzola, Andrzej Krzysztofiak, Annausa Pantosti, Laura Lancella, Paola Bernaschi, Maria Rosaria Marchili, Alberto Villani

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article › peer-review

Abstract

Diseases caused by Streptococcus pneumoniae are mostly preventable infections by current immunization programs. The objective of this study was to evaluate the impact of the introduction of the heptavalent and the 13-valent pneumococcal conjugate vaccines (PCV7 and PCV13) on the burden of pneumococcal disease and on the serotype distribution of S. pneumoniae causing invasive pneumococcal diseases (IPDs) in the pediatric age over a 5-year study (from January 2008 till December 2012). We observed a decrease in IPD rate in children after PCV13 introduction despite increases in nonvaccine serotype (NVS) rates in 2011. Nevertheless, from 2012, an increase in IPD rates due to non-PCV13 serotypes was observed.

Original language	English
Journal	Journal of Pediatric Infectious Diseases
DOIs	https://doi.org/10.1055/s-0037-1615784
Publication status	Accepted/In press - Jan 2 2018

Keywords

children
invasive disease
Streptococcus pneumoniae
vaccine

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Infectious Diseases

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10.1055/s-0037-1615784

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Nicolosi, L., Bozzola, E., Krzysztofiak, A., Pantosti, A., Lancella, L., Bernaschi, P., Marchili, M. R., & Villani, A. (Accepted/In press). Serotype Distribution of Streptococcus pneumoniae causing Invasive Pneumococcal Disease at Bambino Gesù Children's Hospital in Rome: Is It Time for a New Vaccine? Journal of Pediatric Infectious Diseases. https://doi.org/10.1055/s-0037-1615784

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abstract = "Diseases caused by Streptococcus pneumoniae are mostly preventable infections by current immunization programs. The objective of this study was to evaluate the impact of the introduction of the heptavalent and the 13-valent pneumococcal conjugate vaccines (PCV7 and PCV13) on the burden of pneumococcal disease and on the serotype distribution of S. pneumoniae causing invasive pneumococcal diseases (IPDs) in the pediatric age over a 5-year study (from January 2008 till December 2012). We observed a decrease in IPD rate in children after PCV13 introduction despite increases in nonvaccine serotype (NVS) rates in 2011. Nevertheless, from 2012, an increase in IPD rates due to non-PCV13 serotypes was observed. ",

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AU - Nicolosi, Luciana

AU - Bozzola, Elena

AU - Krzysztofiak, Andrzej

AU - Pantosti, Annausa

AU - Lancella, Laura

AU - Bernaschi, Paola

AU - Marchili, Maria Rosaria

AU - Villani, Alberto

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AB - Diseases caused by Streptococcus pneumoniae are mostly preventable infections by current immunization programs. The objective of this study was to evaluate the impact of the introduction of the heptavalent and the 13-valent pneumococcal conjugate vaccines (PCV7 and PCV13) on the burden of pneumococcal disease and on the serotype distribution of S. pneumoniae causing invasive pneumococcal diseases (IPDs) in the pediatric age over a 5-year study (from January 2008 till December 2012). We observed a decrease in IPD rate in children after PCV13 introduction despite increases in nonvaccine serotype (NVS) rates in 2011. Nevertheless, from 2012, an increase in IPD rates due to non-PCV13 serotypes was observed.

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Serotype Distribution of Streptococcus pneumoniae causing Invasive Pneumococcal Disease at Bambino Gesù Children's Hospital in Rome: Is It Time for a New Vaccine?

Abstract

Keywords

ASJC Scopus subject areas

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