Abstract
Diseases caused by Streptococcus pneumoniae are mostly preventable infections by current immunization programs. The objective of this study was to evaluate the impact of the introduction of the heptavalent and the 13-valent pneumococcal conjugate vaccines (PCV7 and PCV13) on the burden of pneumococcal disease and on the serotype distribution of S. pneumoniae causing invasive pneumococcal diseases (IPDs) in the pediatric age over a 5-year study (from January 2008 till December 2012). We observed a decrease in IPD rate in children after PCV13 introduction despite increases in nonvaccine serotype (NVS) rates in 2011. Nevertheless, from 2012, an increase in IPD rates due to non-PCV13 serotypes was observed.
| Original language | English |
|---|---|
| Journal | Journal of Pediatric Infectious Diseases |
| DOIs | |
| Publication status | Accepted/In press - Jan 2 2018 |
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Keywords
- children
- invasive disease
- Streptococcus pneumoniae
- vaccine
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Infectious Diseases
Cite this
Serotype Distribution of Streptococcus pneumoniae causing Invasive Pneumococcal Disease at Bambino Gesù Children's Hospital in Rome : Is It Time for a New Vaccine? / Nicolosi, Luciana; Bozzola, Elena; Krzysztofiak, Andrzej; Pantosti, Annausa; Lancella, Laura; Bernaschi, Paola; Marchili, Maria Rosaria; Villani, Alberto.
In: Journal of Pediatric Infectious Diseases, 02.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serotype Distribution of Streptococcus pneumoniae causing Invasive Pneumococcal Disease at Bambino Gesù Children's Hospital in Rome
T2 - Is It Time for a New Vaccine?
AU - Nicolosi, Luciana
AU - Bozzola, Elena
AU - Krzysztofiak, Andrzej
AU - Pantosti, Annausa
AU - Lancella, Laura
AU - Bernaschi, Paola
AU - Marchili, Maria Rosaria
AU - Villani, Alberto
PY - 2018/1/2
Y1 - 2018/1/2
N2 - Diseases caused by Streptococcus pneumoniae are mostly preventable infections by current immunization programs. The objective of this study was to evaluate the impact of the introduction of the heptavalent and the 13-valent pneumococcal conjugate vaccines (PCV7 and PCV13) on the burden of pneumococcal disease and on the serotype distribution of S. pneumoniae causing invasive pneumococcal diseases (IPDs) in the pediatric age over a 5-year study (from January 2008 till December 2012). We observed a decrease in IPD rate in children after PCV13 introduction despite increases in nonvaccine serotype (NVS) rates in 2011. Nevertheless, from 2012, an increase in IPD rates due to non-PCV13 serotypes was observed.
AB - Diseases caused by Streptococcus pneumoniae are mostly preventable infections by current immunization programs. The objective of this study was to evaluate the impact of the introduction of the heptavalent and the 13-valent pneumococcal conjugate vaccines (PCV7 and PCV13) on the burden of pneumococcal disease and on the serotype distribution of S. pneumoniae causing invasive pneumococcal diseases (IPDs) in the pediatric age over a 5-year study (from January 2008 till December 2012). We observed a decrease in IPD rate in children after PCV13 introduction despite increases in nonvaccine serotype (NVS) rates in 2011. Nevertheless, from 2012, an increase in IPD rates due to non-PCV13 serotypes was observed.
KW - children
KW - invasive disease
KW - Streptococcus pneumoniae
KW - vaccine
UR - http://www.scopus.com/inward/record.url?scp=85040046834&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85040046834&partnerID=8YFLogxK
U2 - 10.1055/s-0037-1615784
DO - 10.1055/s-0037-1615784
M3 - Article
AN - SCOPUS:85040046834
JO - Journal of Pediatric Infectious Diseases
JF - Journal of Pediatric Infectious Diseases
SN - 1871-0336
ER -