Serotype replacement in Streptococcus pneumoniae after conjugate vaccine introduction: Impact, doubts and perspective for new vaccines

Ansaldi Filippo, De Florentiis Daniela, Canepa Paola, Durando Paolo, Bassetti Matteo, Icardi Giancarlo

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The licensed seven-valent pneumococcal conjugate vaccine has successfully reduced invasive pneumococcal disease (IPD) in the USA and in all countries in which it was introduced into national immunization programs, but an increase in the incidence of IPD caused by nonvaccine serotypes has been observed in some areas. This review extended investigation into the effects of PCV7 vaccination on the dynamics of IPD and on the epidemiological picture of circulating serotypes, focusing on mechanisms of pneumococcal escape from vaccination, their impact in terms of reduced effectiveness of PCV7 and the perspective for new vaccines.

Original languageEnglish
Pages (from-to)56-64
Number of pages9
JournalReviews in Medical Microbiology
Volume21
Issue number3
DOIs
Publication statusPublished - Jul 2010

Fingerprint

Conjugate Vaccines
Streptococcus pneumoniae
Vaccines
Vaccination
Immunization Programs
Pneumococcal Vaccines
Incidence
Serogroup

Keywords

  • capsular switching
  • invasive pneumococcal disease
  • pneumococcal vaccination
  • replacement

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Serotype replacement in Streptococcus pneumoniae after conjugate vaccine introduction : Impact, doubts and perspective for new vaccines. / Filippo, Ansaldi; Daniela, De Florentiis; Paola, Canepa; Paolo, Durando; Matteo, Bassetti; Giancarlo, Icardi.

In: Reviews in Medical Microbiology, Vol. 21, No. 3, 07.2010, p. 56-64.

Research output: Contribution to journalArticle

Filippo, Ansaldi ; Daniela, De Florentiis ; Paola, Canepa ; Paolo, Durando ; Matteo, Bassetti ; Giancarlo, Icardi. / Serotype replacement in Streptococcus pneumoniae after conjugate vaccine introduction : Impact, doubts and perspective for new vaccines. In: Reviews in Medical Microbiology. 2010 ; Vol. 21, No. 3. pp. 56-64.
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