Serous cystic neoplasm of the pancreas: A multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas)

B. Jais, V. Rebours, Giuseppe Malleo, R. Salvia, M. Fontana, L. Maggino, C. Bassi, R. Manfredi, R. Moran, A. M. Lennon, A. Zaheer, C. Wolfgang, R. Hruban, Giovanni Marchegiani, Carlos Fernandez-del Castillo, W. Brugge, Y. Ha, M. H. Kim, D. Oh, I. HiraiW. Kimura, J. Y. Jang, S. W. Kim, W. Jung, H. Kang, S. Y. Song, C. M. Kang, W. J. Lee, Stefano Crippa, Massimo Falconi, I. Gomatos, J. Neoptolemos, Anna Caterina Milanetto, C. Sperti, C. Ricci, Riccardo Casadei, Massimiliano Bissolati, Gianpaolo Balzano, I. Frigerio, R. Girelli, M. Delhaye, B. Bernier, H. Wang, K. T. Jang, D. H. Song, M. T. Huggett, K. W. Oppong, L. Pererva, K. V. Kopchak, Marco Del Chiaro, R. Segersvard, L. S. Lee, D. Conwell, A. Osvaldt, V. Campos, G. Aguero Garcete, B. Napoleon, I. Matsumoto, M. Shinzeki, F. Bolado, J. M. Urman Fernandez, M. G. Keane, S. P. Pereira, I. Araujo Acuna, E. C. Vaquero, Maria Rachele Angiolini, Alessandro Zerbi, J. Tang, R. W. Leong, A. Faccinetto, G. Morana, Mariachiara Petrone, Paolo Arcidiacono, J. H. Moon, H. J. Choi, R. S. Gill, D. Pavey, M. Ouaïssi, B. Sastre, M. Spandre, C. G. De Angelis, M. A. Rios-Vives, M. Concepcion-Martin, T. Ikeura, K. Okazaki, Luca Frulloni, O. Messina, P. Lévy

Research output: Contribution to journalArticle

Abstract

Objectives Serous cystic neoplasm (SCN) is a cystic neoplasm of the pancreas whose natural history is poorly known. The purpose of the study was to attempt to describe the natural history of SCN, including the specific mortality. Design Retrospective multinational study including SCN diagnosed between 1990 and 2014. Results 2622 patients were included. Seventy-four per cent were women, and median age at diagnosis was 58 years (16-99). Patients presented with non-specific abdominal pain (27%), pancreaticobiliary symptoms (9%), diabetes mellitus (5%), other symptoms (4%) and/or were asymptomatic (61%). Fifty-two per cent of patients were operated on during the first year after diagnosis (median size: 40 mm (2-200)), 9% had resection beyond 1 year of follow-up (3 years (1-20), size at diagnosis: 25 mm (4- 140)) and 39% had no surgery (3.6 years (1-23), 25.5 mm (1-200)). Surgical indications were (not exclusive) uncertain diagnosis (60%), symptoms (23%), size increase (12%), large size (6%) and adjacent organ compression (5%). In patients followed beyond 1 year (n=1271), size increased in 37% (growth rate: 4 mm/ year), was stable in 57% and decreased in 6%. Three serous cystadenocarcinomas were recorded. Postoperative mortality was 0.6% (n=10), and SCN's related mortality was 0.1% (n=1).

Original languageEnglish
Pages (from-to)305-312
Number of pages8
JournalGut
Volume65
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

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Pancreatic Neoplasms
Pancreas
Natural History
Mortality
Neoplasms
Serous Cystadenocarcinoma
Abdominal Pain
Diabetes Mellitus
Retrospective Studies
Growth

ASJC Scopus subject areas

  • Gastroenterology

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Serous cystic neoplasm of the pancreas : A multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas). / Jais, B.; Rebours, V.; Malleo, Giuseppe; Salvia, R.; Fontana, M.; Maggino, L.; Bassi, C.; Manfredi, R.; Moran, R.; Lennon, A. M.; Zaheer, A.; Wolfgang, C.; Hruban, R.; Marchegiani, Giovanni; Fernandez-del Castillo, Carlos; Brugge, W.; Ha, Y.; Kim, M. H.; Oh, D.; Hirai, I.; Kimura, W.; Jang, J. Y.; Kim, S. W.; Jung, W.; Kang, H.; Song, S. Y.; Kang, C. M.; Lee, W. J.; Crippa, Stefano; Falconi, Massimo; Gomatos, I.; Neoptolemos, J.; Milanetto, Anna Caterina; Sperti, C.; Ricci, C.; Casadei, Riccardo; Bissolati, Massimiliano; Balzano, Gianpaolo; Frigerio, I.; Girelli, R.; Delhaye, M.; Bernier, B.; Wang, H.; Jang, K. T.; Song, D. H.; Huggett, M. T.; Oppong, K. W.; Pererva, L.; Kopchak, K. V.; Del Chiaro, Marco; Segersvard, R.; Lee, L. S.; Conwell, D.; Osvaldt, A.; Campos, V.; Aguero Garcete, G.; Napoleon, B.; Matsumoto, I.; Shinzeki, M.; Bolado, F.; Urman Fernandez, J. M.; Keane, M. G.; Pereira, S. P.; Araujo Acuna, I.; Vaquero, E. C.; Angiolini, Maria Rachele; Zerbi, Alessandro; Tang, J.; Leong, R. W.; Faccinetto, A.; Morana, G.; Petrone, Mariachiara; Arcidiacono, Paolo; Moon, J. H.; Choi, H. J.; Gill, R. S.; Pavey, D.; Ouaïssi, M.; Sastre, B.; Spandre, M.; De Angelis, C. G.; Rios-Vives, M. A.; Concepcion-Martin, M.; Ikeura, T.; Okazaki, K.; Frulloni, Luca; Messina, O.; Lévy, P.

In: Gut, Vol. 65, No. 2, 01.02.2016, p. 305-312.

Research output: Contribution to journalArticle

Jais, B, Rebours, V, Malleo, G, Salvia, R, Fontana, M, Maggino, L, Bassi, C, Manfredi, R, Moran, R, Lennon, AM, Zaheer, A, Wolfgang, C, Hruban, R, Marchegiani, G, Fernandez-del Castillo, C, Brugge, W, Ha, Y, Kim, MH, Oh, D, Hirai, I, Kimura, W, Jang, JY, Kim, SW, Jung, W, Kang, H, Song, SY, Kang, CM, Lee, WJ, Crippa, S, Falconi, M, Gomatos, I, Neoptolemos, J, Milanetto, AC, Sperti, C, Ricci, C, Casadei, R, Bissolati, M, Balzano, G, Frigerio, I, Girelli, R, Delhaye, M, Bernier, B, Wang, H, Jang, KT, Song, DH, Huggett, MT, Oppong, KW, Pererva, L, Kopchak, KV, Del Chiaro, M, Segersvard, R, Lee, LS, Conwell, D, Osvaldt, A, Campos, V, Aguero Garcete, G, Napoleon, B, Matsumoto, I, Shinzeki, M, Bolado, F, Urman Fernandez, JM, Keane, MG, Pereira, SP, Araujo Acuna, I, Vaquero, EC, Angiolini, MR, Zerbi, A, Tang, J, Leong, RW, Faccinetto, A, Morana, G, Petrone, M, Arcidiacono, P, Moon, JH, Choi, HJ, Gill, RS, Pavey, D, Ouaïssi, M, Sastre, B, Spandre, M, De Angelis, CG, Rios-Vives, MA, Concepcion-Martin, M, Ikeura, T, Okazaki, K, Frulloni, L, Messina, O & Lévy, P 2016, 'Serous cystic neoplasm of the pancreas: A multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas)', Gut, vol. 65, no. 2, pp. 305-312. https://doi.org/10.1136/gutjnl-2015-309638
Jais, B. ; Rebours, V. ; Malleo, Giuseppe ; Salvia, R. ; Fontana, M. ; Maggino, L. ; Bassi, C. ; Manfredi, R. ; Moran, R. ; Lennon, A. M. ; Zaheer, A. ; Wolfgang, C. ; Hruban, R. ; Marchegiani, Giovanni ; Fernandez-del Castillo, Carlos ; Brugge, W. ; Ha, Y. ; Kim, M. H. ; Oh, D. ; Hirai, I. ; Kimura, W. ; Jang, J. Y. ; Kim, S. W. ; Jung, W. ; Kang, H. ; Song, S. Y. ; Kang, C. M. ; Lee, W. J. ; Crippa, Stefano ; Falconi, Massimo ; Gomatos, I. ; Neoptolemos, J. ; Milanetto, Anna Caterina ; Sperti, C. ; Ricci, C. ; Casadei, Riccardo ; Bissolati, Massimiliano ; Balzano, Gianpaolo ; Frigerio, I. ; Girelli, R. ; Delhaye, M. ; Bernier, B. ; Wang, H. ; Jang, K. T. ; Song, D. H. ; Huggett, M. T. ; Oppong, K. W. ; Pererva, L. ; Kopchak, K. V. ; Del Chiaro, Marco ; Segersvard, R. ; Lee, L. S. ; Conwell, D. ; Osvaldt, A. ; Campos, V. ; Aguero Garcete, G. ; Napoleon, B. ; Matsumoto, I. ; Shinzeki, M. ; Bolado, F. ; Urman Fernandez, J. M. ; Keane, M. G. ; Pereira, S. P. ; Araujo Acuna, I. ; Vaquero, E. C. ; Angiolini, Maria Rachele ; Zerbi, Alessandro ; Tang, J. ; Leong, R. W. ; Faccinetto, A. ; Morana, G. ; Petrone, Mariachiara ; Arcidiacono, Paolo ; Moon, J. H. ; Choi, H. J. ; Gill, R. S. ; Pavey, D. ; Ouaïssi, M. ; Sastre, B. ; Spandre, M. ; De Angelis, C. G. ; Rios-Vives, M. A. ; Concepcion-Martin, M. ; Ikeura, T. ; Okazaki, K. ; Frulloni, Luca ; Messina, O. ; Lévy, P. / Serous cystic neoplasm of the pancreas : A multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas). In: Gut. 2016 ; Vol. 65, No. 2. pp. 305-312.
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abstract = "Objectives Serous cystic neoplasm (SCN) is a cystic neoplasm of the pancreas whose natural history is poorly known. The purpose of the study was to attempt to describe the natural history of SCN, including the specific mortality. Design Retrospective multinational study including SCN diagnosed between 1990 and 2014. Results 2622 patients were included. Seventy-four per cent were women, and median age at diagnosis was 58 years (16-99). Patients presented with non-specific abdominal pain (27{\%}), pancreaticobiliary symptoms (9{\%}), diabetes mellitus (5{\%}), other symptoms (4{\%}) and/or were asymptomatic (61{\%}). Fifty-two per cent of patients were operated on during the first year after diagnosis (median size: 40 mm (2-200)), 9{\%} had resection beyond 1 year of follow-up (3 years (1-20), size at diagnosis: 25 mm (4- 140)) and 39{\%} had no surgery (3.6 years (1-23), 25.5 mm (1-200)). Surgical indications were (not exclusive) uncertain diagnosis (60{\%}), symptoms (23{\%}), size increase (12{\%}), large size (6{\%}) and adjacent organ compression (5{\%}). In patients followed beyond 1 year (n=1271), size increased in 37{\%} (growth rate: 4 mm/ year), was stable in 57{\%} and decreased in 6{\%}. Three serous cystadenocarcinomas were recorded. Postoperative mortality was 0.6{\%} (n=10), and SCN's related mortality was 0.1{\%} (n=1).",
author = "B. Jais and V. Rebours and Giuseppe Malleo and R. Salvia and M. Fontana and L. Maggino and C. Bassi and R. Manfredi and R. Moran and Lennon, {A. M.} and A. Zaheer and C. Wolfgang and R. Hruban and Giovanni Marchegiani and {Fernandez-del Castillo}, Carlos and W. Brugge and Y. Ha and Kim, {M. H.} and D. Oh and I. Hirai and W. Kimura and Jang, {J. Y.} and Kim, {S. W.} and W. Jung and H. Kang and Song, {S. Y.} and Kang, {C. M.} and Lee, {W. J.} and Stefano Crippa and Massimo Falconi and I. Gomatos and J. Neoptolemos and Milanetto, {Anna Caterina} and C. Sperti and C. Ricci and Riccardo Casadei and Massimiliano Bissolati and Gianpaolo Balzano and I. Frigerio and R. Girelli and M. Delhaye and B. Bernier and H. Wang and Jang, {K. T.} and Song, {D. H.} and Huggett, {M. T.} and Oppong, {K. W.} and L. Pererva and Kopchak, {K. V.} and {Del Chiaro}, Marco and R. Segersvard and Lee, {L. S.} and D. Conwell and A. Osvaldt and V. Campos and {Aguero Garcete}, G. and B. Napoleon and I. Matsumoto and M. Shinzeki and F. Bolado and {Urman Fernandez}, {J. M.} and Keane, {M. G.} and Pereira, {S. P.} and {Araujo Acuna}, I. and Vaquero, {E. C.} and Angiolini, {Maria Rachele} and Alessandro Zerbi and J. Tang and Leong, {R. W.} and A. Faccinetto and G. Morana and Mariachiara Petrone and Paolo Arcidiacono and Moon, {J. H.} and Choi, {H. J.} and Gill, {R. S.} and D. Pavey and M. Oua{\"i}ssi and B. Sastre and M. Spandre and {De Angelis}, {C. G.} and Rios-Vives, {M. A.} and M. Concepcion-Martin and T. Ikeura and K. Okazaki and Luca Frulloni and O. Messina and P. L{\'e}vy",
year = "2016",
month = "2",
day = "1",
doi = "10.1136/gutjnl-2015-309638",
language = "English",
volume = "65",
pages = "305--312",
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TY - JOUR

T1 - Serous cystic neoplasm of the pancreas

T2 - A multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas)

AU - Jais, B.

AU - Rebours, V.

AU - Malleo, Giuseppe

AU - Salvia, R.

AU - Fontana, M.

AU - Maggino, L.

AU - Bassi, C.

AU - Manfredi, R.

AU - Moran, R.

AU - Lennon, A. M.

AU - Zaheer, A.

AU - Wolfgang, C.

AU - Hruban, R.

AU - Marchegiani, Giovanni

AU - Fernandez-del Castillo, Carlos

AU - Brugge, W.

AU - Ha, Y.

AU - Kim, M. H.

AU - Oh, D.

AU - Hirai, I.

AU - Kimura, W.

AU - Jang, J. Y.

AU - Kim, S. W.

AU - Jung, W.

AU - Kang, H.

AU - Song, S. Y.

AU - Kang, C. M.

AU - Lee, W. J.

AU - Crippa, Stefano

AU - Falconi, Massimo

AU - Gomatos, I.

AU - Neoptolemos, J.

AU - Milanetto, Anna Caterina

AU - Sperti, C.

AU - Ricci, C.

AU - Casadei, Riccardo

AU - Bissolati, Massimiliano

AU - Balzano, Gianpaolo

AU - Frigerio, I.

AU - Girelli, R.

AU - Delhaye, M.

AU - Bernier, B.

AU - Wang, H.

AU - Jang, K. T.

AU - Song, D. H.

AU - Huggett, M. T.

AU - Oppong, K. W.

AU - Pererva, L.

AU - Kopchak, K. V.

AU - Del Chiaro, Marco

AU - Segersvard, R.

AU - Lee, L. S.

AU - Conwell, D.

AU - Osvaldt, A.

AU - Campos, V.

AU - Aguero Garcete, G.

AU - Napoleon, B.

AU - Matsumoto, I.

AU - Shinzeki, M.

AU - Bolado, F.

AU - Urman Fernandez, J. M.

AU - Keane, M. G.

AU - Pereira, S. P.

AU - Araujo Acuna, I.

AU - Vaquero, E. C.

AU - Angiolini, Maria Rachele

AU - Zerbi, Alessandro

AU - Tang, J.

AU - Leong, R. W.

AU - Faccinetto, A.

AU - Morana, G.

AU - Petrone, Mariachiara

AU - Arcidiacono, Paolo

AU - Moon, J. H.

AU - Choi, H. J.

AU - Gill, R. S.

AU - Pavey, D.

AU - Ouaïssi, M.

AU - Sastre, B.

AU - Spandre, M.

AU - De Angelis, C. G.

AU - Rios-Vives, M. A.

AU - Concepcion-Martin, M.

AU - Ikeura, T.

AU - Okazaki, K.

AU - Frulloni, Luca

AU - Messina, O.

AU - Lévy, P.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Objectives Serous cystic neoplasm (SCN) is a cystic neoplasm of the pancreas whose natural history is poorly known. The purpose of the study was to attempt to describe the natural history of SCN, including the specific mortality. Design Retrospective multinational study including SCN diagnosed between 1990 and 2014. Results 2622 patients were included. Seventy-four per cent were women, and median age at diagnosis was 58 years (16-99). Patients presented with non-specific abdominal pain (27%), pancreaticobiliary symptoms (9%), diabetes mellitus (5%), other symptoms (4%) and/or were asymptomatic (61%). Fifty-two per cent of patients were operated on during the first year after diagnosis (median size: 40 mm (2-200)), 9% had resection beyond 1 year of follow-up (3 years (1-20), size at diagnosis: 25 mm (4- 140)) and 39% had no surgery (3.6 years (1-23), 25.5 mm (1-200)). Surgical indications were (not exclusive) uncertain diagnosis (60%), symptoms (23%), size increase (12%), large size (6%) and adjacent organ compression (5%). In patients followed beyond 1 year (n=1271), size increased in 37% (growth rate: 4 mm/ year), was stable in 57% and decreased in 6%. Three serous cystadenocarcinomas were recorded. Postoperative mortality was 0.6% (n=10), and SCN's related mortality was 0.1% (n=1).

AB - Objectives Serous cystic neoplasm (SCN) is a cystic neoplasm of the pancreas whose natural history is poorly known. The purpose of the study was to attempt to describe the natural history of SCN, including the specific mortality. Design Retrospective multinational study including SCN diagnosed between 1990 and 2014. Results 2622 patients were included. Seventy-four per cent were women, and median age at diagnosis was 58 years (16-99). Patients presented with non-specific abdominal pain (27%), pancreaticobiliary symptoms (9%), diabetes mellitus (5%), other symptoms (4%) and/or were asymptomatic (61%). Fifty-two per cent of patients were operated on during the first year after diagnosis (median size: 40 mm (2-200)), 9% had resection beyond 1 year of follow-up (3 years (1-20), size at diagnosis: 25 mm (4- 140)) and 39% had no surgery (3.6 years (1-23), 25.5 mm (1-200)). Surgical indications were (not exclusive) uncertain diagnosis (60%), symptoms (23%), size increase (12%), large size (6%) and adjacent organ compression (5%). In patients followed beyond 1 year (n=1271), size increased in 37% (growth rate: 4 mm/ year), was stable in 57% and decreased in 6%. Three serous cystadenocarcinomas were recorded. Postoperative mortality was 0.6% (n=10), and SCN's related mortality was 0.1% (n=1).

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U2 - 10.1136/gutjnl-2015-309638

DO - 10.1136/gutjnl-2015-309638

M3 - Article

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EP - 312

JO - Gut

JF - Gut

SN - 0017-5749

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ER -