Sertraline treatment for depression associated with acute coronary syndromes: A cost analysis from the viewpoint of the Italian Healthcare System

Fabrizia Lattanzio, Antonio Cherubini, Gianluca Furneri, Mauro Di Bari, Niccolò Marchionni

Research output: Contribution to journalArticlepeer-review

Abstract

Background and aims: Depressive disorders (DD) are independent risk factors for rehospitalization after acute coronary syndromes (ACS) and, hence, for increased healthcare costs. A placebo-controlled safety trial of 24 weeks of treatment with sertraline after ACS (Sertraline Anti-Depressant Heart Attack Randomized Trial, SADHART) suggested that active treatment was associated with reduced rehospitalization due to coronary and non-coronary events. With the SADHART database, a cost analysis was carried out to determine the economic consequences of treating DD after ACS in the perspective of the Italian Healthcare System. Methods: Clinical information on medical events and rehospitalizations recorded over the study period was drawn from the original SADHART database, which did not contain information necessary for estimating indirect costs. Analysis was therefore limited to direct medical costs due to rehospitalizations, emergency room visits and hospital procedures, and the average Italian Diagnosis-Related Group (DRG) tariffs were applied. Results: With the exclusion of the cost of sertraline treatment, the average direct cost per patient over the study period was 3,418±8,290 € in the active treatment group and 4,409±9,439 € in the placebo group (p=0.3). After including the cost of 24 weeks of sertraline treatment, the average cost in sertraline-treated patients was only modestly increased, to 3,524±8,290 €. Conclusions: Treatment of major DD in patients with recent ACS can improve patient care without additional costs, and possibly with some savings, to the healthcare system.

Original languageEnglish
Pages (from-to)76-80
Number of pages5
JournalAging clinical and experimental research
Volume20
Issue number1
Publication statusPublished - Feb 2008

Keywords

  • Aging
  • Coronary heart disease
  • Cost analysis
  • Depression

ASJC Scopus subject areas

  • Ageing

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