Serum α-klotho levels are not informative for the evaluation of growth hormone secretion in short children

Cristina Meazza, Heba H. Elsedfy, Randa I. Khalaf, Fiorenzo Lupi, Sara Pagani, Mohamed El Kholy, Carmine Tinelli, Giorgio Radetti, Mauro Bozzola

Research output: Contribution to journalArticle

Abstract

α-Klotho is a transmembrane protein that can be cleaved and act as a circulating hormone (s-klotho). s-Klotho serum levels seem to reflect growth hormone (GH) secretory status. We investigated the role of s-klotho as a reliable marker of GH secretion in short children and the factors influencing its secretion. We enrolled 40 short Egyptian children (20 GH deficiency [GHD] and 20 idiopathic short stature [ISS]). They underwent a pegvisomant-primed insulin tolerance test (ITT) and were accordingly reclassified as 16 GHD and 24 ISS. The samples obtained before and 3 days after pegvisomant administration, prior to the ITT, were used for assaying insulin-like growth factor (IGF)-I and s-klotho. IGF-I and s-klotho serum levels were not significantly different (p=0.059 and p=0.212, respectively) between GHD and ISS. After pegvisomant, a significant reduction in IGF-I and s-klotho levels was found in both groups. s-Klotho significantly correlated only with IGF-I levels in both groups. s-Klotho mainly reflects the IGF-I status and cannot be considered a reliable biomarker for GH secretion in children.

Original languageEnglish
Pages (from-to)1055-1059
Number of pages5
JournalJournal of Pediatric Endocrinology and Metabolism
Volume30
Issue number10
DOIs
Publication statusPublished - Oct 26 2017

Fingerprint

Insulin-Like Growth Factor I
Growth Hormone
Serum
Insulin
Biomarkers
Hormones
pegvisomant
Proteins

Keywords

  • children
  • growth hormone (GH) deficiency diagnosis
  • IGF-I
  • klotho

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Serum α-klotho levels are not informative for the evaluation of growth hormone secretion in short children. / Meazza, Cristina; Elsedfy, Heba H.; Khalaf, Randa I.; Lupi, Fiorenzo; Pagani, Sara; Kholy, Mohamed El; Tinelli, Carmine; Radetti, Giorgio; Bozzola, Mauro.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 30, No. 10, 26.10.2017, p. 1055-1059.

Research output: Contribution to journalArticle

Meazza, Cristina ; Elsedfy, Heba H. ; Khalaf, Randa I. ; Lupi, Fiorenzo ; Pagani, Sara ; Kholy, Mohamed El ; Tinelli, Carmine ; Radetti, Giorgio ; Bozzola, Mauro. / Serum α-klotho levels are not informative for the evaluation of growth hormone secretion in short children. In: Journal of Pediatric Endocrinology and Metabolism. 2017 ; Vol. 30, No. 10. pp. 1055-1059.
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