Serum 25-hydroxyvitamin D concentration in subclinical carotid atherosclerosis

Anna Deleskog, Olga Piksasova, Angela Silveira, Karl Gertow, Damiano Baldassarre, Fabrizio Veglia, Bengt Sennblad, Rona J. Strawbridge, Malin Larsson, Karin Leander, Bruna Gigante, Jussi Kauhanen, Rainer Rauramaa, Andries J. Smit, Elmo Mannarino, Philippe Giral, Sven Gustafsson, Claes Göran Östenson, Steve E. Humphries, Elena TremoliUlf De Faire, John Öhrvik, Anders Hamsten

Research output: Contribution to journalArticle


OBJECTIVE-: Vitamin D deficiency has been implicated in cardiovascular disease and is associated with multiple cardiovascular risk factors. We investigated the serum 25-hydroxyvitamin D (25(OH)D) concentration in relation to latitude, baseline carotid intima-media thickness (IMT), and IMT progression, the carotid IMT measures being surrogate markers of subclinical atherosclerosis and cardiovascular disease risk. APPROACH AND RESULTS-: Serum 25(OH)D concentration was related to high-resolution carotid IMT measures in 3430 middle-aged and elderly subjects with high cardiovascular risk but no prevalent disease, who were recruited at 7 centers in Finland, Sweden, The Netherlands, France, and Italy. Participants underwent carotid ultrasound examination at baseline and at months 15 and 30 after entry into the study, whereas blood samples, clinical data, and information about lifestyle were collected at baseline. Serum 25(OH)D levels were positively associated with latitude (Jonckheere-Terpstra χ=166.643; P

Original languageEnglish
Pages (from-to)2633-2638
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Issue number11
Publication statusPublished - Nov 2013


  • 25-hydroxyvitamin D
  • cardiovascular diseases
  • carotid intimal medial thickness 1
  • risk factors
  • vitamin D

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Deleskog, A., Piksasova, O., Silveira, A., Gertow, K., Baldassarre, D., Veglia, F., Sennblad, B., Strawbridge, R. J., Larsson, M., Leander, K., Gigante, B., Kauhanen, J., Rauramaa, R., Smit, A. J., Mannarino, E., Giral, P., Gustafsson, S., Östenson, C. G., Humphries, S. E., ... Hamsten, A. (2013). Serum 25-hydroxyvitamin D concentration in subclinical carotid atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 33(11), 2633-2638.