Serum 90K/Mac-2 binding protein (Mac-2BP) as a response predictor to peginterferon and ribavirin combined treatment in Hcv chronic patients

Palma A. Iacovazzi, Raffaele Cozzolongo, Elsa Lanzillotta, Stefania Frisullo, Vito Guerra, Mario Correale

Research output: Contribution to journalArticlepeer-review

Abstract

90K/Mac-2BP glycoprotein is involved in the immune defense against a variety of neoplasms and viral infections, modulating the activity of several effectors such as natural killer cells. Quite interestingly, 90K/Mac-2BP is associated to a poor response to interferon (IFN) α in hepatitis C virus (HCV) infected patients. Here, in 70 consecutive HCV chronic patients, we have evaluated 90K basal levels as a response predictor to combined therapy with Peginterferon and Ribavirin. We have found higher 90K levels in genotype 1/4 than in genotype 2/3 (p = 0.006) and in 62.5% of non-responders than in 20% of responders (p <0.001). Genotype 1/4, higher 90K and gamma glutamyl transferase (γGT) levels resulted independently associated to a status of refractoriness to therapy. Consequently, evaluation of 90K serum levels seems to be a promising useful marker of response to combined therapy in HCV disease.

Original languageEnglish
Pages (from-to)687-700
Number of pages14
JournalImmunopharmacology and Immunotoxicology
Volume30
Issue number4
DOIs
Publication statusPublished - Dec 2008

Keywords

  • 90K/Mac-2BP
  • Hepatitis C
  • Treatment

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology

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