Serum adiponectin and glomerular filtration rate in patients with type 2 diabetes

Lorena Ortega Moreno, Olga Lamacchia, Massimiliano Copetti, Lucia Salvemini, Concetta De Bonis, Salvatore De Cosmo, Mauro Cignarelli, Vincenzo Trischitta, Claudia Menzaghi

Research output: Contribution to journalArticlepeer-review


High serum adiponectin has been increased in several conditions of kidney disease. Only sparse and conflicting results have been reported in patients with type 2 diabetes (T2D), a subgroup of individuals who are at high risk for renal dysfunction. The aim of this study was to fill up this gap of knowledge by investigating such association in a large sample of Italian diabetic patients. The association between serum adiponectin levels and estimated glomerular filtration rate (eGFR by Chronic Kidney Disease-Epidemiology Collaboration CKD-EPI equation) was investigated in 1,243 patients with T2D from two cross-sectional Italian studies: 878 from San Giovanni Rotondo (SGR) and 365 from Foggia (FG). Serum adiponectin was inversely associated with eGFR in SGR [β (standard error, SE) for 1 standard deviation (SD) of adiponectin = -3.26 (0.64)] and in FG [β(SE)=-5.70(1.28)] sample, as well as in the two studies combined [β(SE)=-3.99(0.59)];(p

Original languageEnglish
Article number0140631
JournalPLoS One
Issue number10
Publication statusPublished - Oct 14 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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