Serum adiponectin and glomerular filtration rate in patients with type 2 diabetes

Lorena Ortega Moreno, Olga Lamacchia, Massimiliano Copetti, Lucia Salvemini, Concetta De Bonis, Salvatore De Cosmo, Mauro Cignarelli, Vincenzo Trischitta, Claudia Menzaghi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

High serum adiponectin has been increased in several conditions of kidney disease. Only sparse and conflicting results have been reported in patients with type 2 diabetes (T2D), a subgroup of individuals who are at high risk for renal dysfunction. The aim of this study was to fill up this gap of knowledge by investigating such association in a large sample of Italian diabetic patients. The association between serum adiponectin levels and estimated glomerular filtration rate (eGFR by Chronic Kidney Disease-Epidemiology Collaboration CKD-EPI equation) was investigated in 1,243 patients with T2D from two cross-sectional Italian studies: 878 from San Giovanni Rotondo (SGR) and 365 from Foggia (FG). Serum adiponectin was inversely associated with eGFR in SGR [β (standard error, SE) for 1 standard deviation (SD) of adiponectin = -3.26 (0.64)] and in FG [β(SE)=-5.70(1.28)] sample, as well as in the two studies combined [β(SE)=-3.99(0.59)];(p

Original languageEnglish
Article number0140631
JournalPLoS One
Volume10
Issue number10
DOIs
Publication statusPublished - Oct 14 2015

Fingerprint

adiponectin
glomerular filtration rate
Adiponectin
Medical problems
Glomerular Filtration Rate
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
kidney diseases
Serum
Epidemiology
Kidney Diseases
Chronic Renal Insufficiency
epidemiology
Cross-Sectional Studies
kidneys
Kidney
sampling

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Serum adiponectin and glomerular filtration rate in patients with type 2 diabetes. / Moreno, Lorena Ortega; Lamacchia, Olga; Copetti, Massimiliano; Salvemini, Lucia; De Bonis, Concetta; De Cosmo, Salvatore; Cignarelli, Mauro; Trischitta, Vincenzo; Menzaghi, Claudia.

In: PLoS One, Vol. 10, No. 10, 0140631, 14.10.2015.

Research output: Contribution to journalArticle

Moreno, Lorena Ortega ; Lamacchia, Olga ; Copetti, Massimiliano ; Salvemini, Lucia ; De Bonis, Concetta ; De Cosmo, Salvatore ; Cignarelli, Mauro ; Trischitta, Vincenzo ; Menzaghi, Claudia. / Serum adiponectin and glomerular filtration rate in patients with type 2 diabetes. In: PLoS One. 2015 ; Vol. 10, No. 10.
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