Serum adiponectin levels are associated with presence of carotid plaque in women with systemic lupus erythematosus

Federico Carbone, Fabrizio Montecucco, Alessandro Poggi, Flavio Nobili, Fabio Cacciapaglia, Antonella Afeltra, Tiziano Moccetti, Barbara M. Colombo

Research output: Contribution to journalArticlepeer-review


Background and aim: Systemic lupus erythematosus (SLE) is associated with accelerated atherogenesis. Traditional risk factors do not seem to fully explain this process in patients with SLE and no other imaging/serum biomarkers have so far improved risk stratification. Here, we focused on the role of adiponectin in women with SLE. Methods and results: This is a sub-analysis of a validated cohort enrolling eighty females (age 18–65 years) affected by SLE. Patient underwent a single blood sampling and carotid echography. Serum adipocytokines (i.e. leptin, resistin and adiponectin) were assessed by enzyme-linked immunosorbent assay (ELISA). Patients with a carotid plaque (n = 23) were older, with longer duration of the disease, chronic use of corticosteroids, and immunosuppressive therapies. As expected, patients with a carotid plaque had increased vascular risk and high serum levels of inflammatory biomarkers, total and LDL cholesterol and adiponectin. Significant positive correlation between serum adiponectin and presence of a carotid plaque was found independently of patient age, SCORE Risk Charts, duration of disease, and SLE treatments. Conclusions: These results indicate that high serum adiponectin is associated with accelerated carotid atherosclerosis in SLE young women and it might be useful to improve vascular risk stratification in this patient setting.

Original languageEnglish
Pages (from-to)1147-1151
Number of pages5
JournalNutrition, Metabolism and Cardiovascular Diseases
Issue number7
Publication statusPublished - Jun 25 2020


  • Adipocytokines
  • Adiponectin
  • Atherosclerosis
  • Leptin resistin
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine


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