Serum aldosterone concentration and cardiovascular risk in women with polycystic ovarian syndrome

Teresa Cascella, Stefano Palomba, Libuse Tauchmanovà, Francesco Manguso, Sebastiano Di Biase, Donato Labella, Francesco Giallauria, Carlo Vigorito, Annamaria Colao, Gaetano Lombardi, Francesco Orio

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Context: Polycystic ovary syndrome (PCOS) is associated with early impairment of vascular structure and a low-grade chronic inflammation. Aldosterone is a well-recognized cardiovascular risk (CVR) factor and is related to inflammatory processes. Objective: Our objective was to investigate serum aldosterone levels in PCOS and correlate them to some CVR factors and early atherosclerotic markers. Design and Setting: A prospective baseline-controlled clinical study was conducted at the University "Federico II" of Naples School of Medicine (Naples, Italy). Patients: Fifty PCOS women age- and body mass index-matched with 50 healthy women were enrolled. Mean Outcome Measures: Anthropometric, hormonal, and metabolic patterns, including plasma aldosterone, renin, and C-reactive protein, were measured in each subject. Intima-media thickness was also evaluated in each patient and control. Results: Aldosterone levels were significantly increased (P <0.001) in PCOS compared with healthy women (10.5 ± 3.2 vs. 5.7 ± 2.5 ng/dl). In PCOS, a significant (P <0.001) direct correlation between plasma aldosterone and homeostasis model assessment, C-reactive protein, intima-media thickness, and mean blood pressure was found. On the other hand, high-density lipoprotein cholesterol and potassium were inversely (P <0.001) related to serum aldosterone. Multiple linear regression analysis showed that the area under the curve for insulin and homeostasis model assessment was linearly related to aldosterone in PCOS. Conclusion: PCOS women show an insulin resistance related increase in serum aldosterone levels.

Original languageEnglish
Pages (from-to)4395-4400
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume91
Issue number11
DOIs
Publication statusPublished - Nov 2006

Fingerprint

Polycystic Ovary Syndrome
Aldosterone
Serum
C-Reactive Protein
Homeostasis
Insulin
Plasmas
Blood pressure
Renin
Linear regression
Regression analysis
HDL Cholesterol
Italy
Medicine
Area Under Curve
Blood Vessels
Insulin Resistance
Linear Models
Potassium
Body Mass Index

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Cascella, T., Palomba, S., Tauchmanovà, L., Manguso, F., Di Biase, S., Labella, D., ... Orio, F. (2006). Serum aldosterone concentration and cardiovascular risk in women with polycystic ovarian syndrome. Journal of Clinical Endocrinology and Metabolism, 91(11), 4395-4400. https://doi.org/10.1210/jc.2006-0399

Serum aldosterone concentration and cardiovascular risk in women with polycystic ovarian syndrome. / Cascella, Teresa; Palomba, Stefano; Tauchmanovà, Libuse; Manguso, Francesco; Di Biase, Sebastiano; Labella, Donato; Giallauria, Francesco; Vigorito, Carlo; Colao, Annamaria; Lombardi, Gaetano; Orio, Francesco.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 91, No. 11, 11.2006, p. 4395-4400.

Research output: Contribution to journalArticle

Cascella, T, Palomba, S, Tauchmanovà, L, Manguso, F, Di Biase, S, Labella, D, Giallauria, F, Vigorito, C, Colao, A, Lombardi, G & Orio, F 2006, 'Serum aldosterone concentration and cardiovascular risk in women with polycystic ovarian syndrome', Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 11, pp. 4395-4400. https://doi.org/10.1210/jc.2006-0399
Cascella, Teresa ; Palomba, Stefano ; Tauchmanovà, Libuse ; Manguso, Francesco ; Di Biase, Sebastiano ; Labella, Donato ; Giallauria, Francesco ; Vigorito, Carlo ; Colao, Annamaria ; Lombardi, Gaetano ; Orio, Francesco. / Serum aldosterone concentration and cardiovascular risk in women with polycystic ovarian syndrome. In: Journal of Clinical Endocrinology and Metabolism. 2006 ; Vol. 91, No. 11. pp. 4395-4400.
@article{ec5724ccd5e74f4087b8580c509c15be,
title = "Serum aldosterone concentration and cardiovascular risk in women with polycystic ovarian syndrome",
abstract = "Context: Polycystic ovary syndrome (PCOS) is associated with early impairment of vascular structure and a low-grade chronic inflammation. Aldosterone is a well-recognized cardiovascular risk (CVR) factor and is related to inflammatory processes. Objective: Our objective was to investigate serum aldosterone levels in PCOS and correlate them to some CVR factors and early atherosclerotic markers. Design and Setting: A prospective baseline-controlled clinical study was conducted at the University {"}Federico II{"} of Naples School of Medicine (Naples, Italy). Patients: Fifty PCOS women age- and body mass index-matched with 50 healthy women were enrolled. Mean Outcome Measures: Anthropometric, hormonal, and metabolic patterns, including plasma aldosterone, renin, and C-reactive protein, were measured in each subject. Intima-media thickness was also evaluated in each patient and control. Results: Aldosterone levels were significantly increased (P <0.001) in PCOS compared with healthy women (10.5 ± 3.2 vs. 5.7 ± 2.5 ng/dl). In PCOS, a significant (P <0.001) direct correlation between plasma aldosterone and homeostasis model assessment, C-reactive protein, intima-media thickness, and mean blood pressure was found. On the other hand, high-density lipoprotein cholesterol and potassium were inversely (P <0.001) related to serum aldosterone. Multiple linear regression analysis showed that the area under the curve for insulin and homeostasis model assessment was linearly related to aldosterone in PCOS. Conclusion: PCOS women show an insulin resistance related increase in serum aldosterone levels.",
author = "Teresa Cascella and Stefano Palomba and Libuse Tauchmanov{\`a} and Francesco Manguso and {Di Biase}, Sebastiano and Donato Labella and Francesco Giallauria and Carlo Vigorito and Annamaria Colao and Gaetano Lombardi and Francesco Orio",
year = "2006",
month = "11",
doi = "10.1210/jc.2006-0399",
language = "English",
volume = "91",
pages = "4395--4400",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "11",

}

TY - JOUR

T1 - Serum aldosterone concentration and cardiovascular risk in women with polycystic ovarian syndrome

AU - Cascella, Teresa

AU - Palomba, Stefano

AU - Tauchmanovà, Libuse

AU - Manguso, Francesco

AU - Di Biase, Sebastiano

AU - Labella, Donato

AU - Giallauria, Francesco

AU - Vigorito, Carlo

AU - Colao, Annamaria

AU - Lombardi, Gaetano

AU - Orio, Francesco

PY - 2006/11

Y1 - 2006/11

N2 - Context: Polycystic ovary syndrome (PCOS) is associated with early impairment of vascular structure and a low-grade chronic inflammation. Aldosterone is a well-recognized cardiovascular risk (CVR) factor and is related to inflammatory processes. Objective: Our objective was to investigate serum aldosterone levels in PCOS and correlate them to some CVR factors and early atherosclerotic markers. Design and Setting: A prospective baseline-controlled clinical study was conducted at the University "Federico II" of Naples School of Medicine (Naples, Italy). Patients: Fifty PCOS women age- and body mass index-matched with 50 healthy women were enrolled. Mean Outcome Measures: Anthropometric, hormonal, and metabolic patterns, including plasma aldosterone, renin, and C-reactive protein, were measured in each subject. Intima-media thickness was also evaluated in each patient and control. Results: Aldosterone levels were significantly increased (P <0.001) in PCOS compared with healthy women (10.5 ± 3.2 vs. 5.7 ± 2.5 ng/dl). In PCOS, a significant (P <0.001) direct correlation between plasma aldosterone and homeostasis model assessment, C-reactive protein, intima-media thickness, and mean blood pressure was found. On the other hand, high-density lipoprotein cholesterol and potassium were inversely (P <0.001) related to serum aldosterone. Multiple linear regression analysis showed that the area under the curve for insulin and homeostasis model assessment was linearly related to aldosterone in PCOS. Conclusion: PCOS women show an insulin resistance related increase in serum aldosterone levels.

AB - Context: Polycystic ovary syndrome (PCOS) is associated with early impairment of vascular structure and a low-grade chronic inflammation. Aldosterone is a well-recognized cardiovascular risk (CVR) factor and is related to inflammatory processes. Objective: Our objective was to investigate serum aldosterone levels in PCOS and correlate them to some CVR factors and early atherosclerotic markers. Design and Setting: A prospective baseline-controlled clinical study was conducted at the University "Federico II" of Naples School of Medicine (Naples, Italy). Patients: Fifty PCOS women age- and body mass index-matched with 50 healthy women were enrolled. Mean Outcome Measures: Anthropometric, hormonal, and metabolic patterns, including plasma aldosterone, renin, and C-reactive protein, were measured in each subject. Intima-media thickness was also evaluated in each patient and control. Results: Aldosterone levels were significantly increased (P <0.001) in PCOS compared with healthy women (10.5 ± 3.2 vs. 5.7 ± 2.5 ng/dl). In PCOS, a significant (P <0.001) direct correlation between plasma aldosterone and homeostasis model assessment, C-reactive protein, intima-media thickness, and mean blood pressure was found. On the other hand, high-density lipoprotein cholesterol and potassium were inversely (P <0.001) related to serum aldosterone. Multiple linear regression analysis showed that the area under the curve for insulin and homeostasis model assessment was linearly related to aldosterone in PCOS. Conclusion: PCOS women show an insulin resistance related increase in serum aldosterone levels.

UR - http://www.scopus.com/inward/record.url?scp=33751501726&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33751501726&partnerID=8YFLogxK

U2 - 10.1210/jc.2006-0399

DO - 10.1210/jc.2006-0399

M3 - Article

C2 - 16940454

AN - SCOPUS:33751501726

VL - 91

SP - 4395

EP - 4400

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 11

ER -